What does megaloblastic anemia mean?

Definitions for megaloblastic anemia
mega·loblas·tic ane·mi·a

This dictionary definitions page includes all the possible meanings, example usage and translations of the word megaloblastic anemia.

Princeton's WordNet

  1. megaloblastic anemia, megaloblastic anaemianoun

    anemia characterized by many large immature and dysfunctional red blood cells (megaloblasts) in the bone marrow; associated with pernicious anemia

Wikipedia

  1. Megaloblastic anemia

    Megaloblastic anemia is a type of macrocytic anemia. An anemia is a red blood cell defect that can lead to an undersupply of oxygen. Megaloblastic anemia results from inhibition of DNA synthesis during red blood cell production. When DNA synthesis is impaired, the cell cycle cannot progress from the G2 growth stage to the mitosis (M) stage. This leads to continuing cell growth without division, which presents as macrocytosis. Megaloblastic anemia has a rather slow onset, especially when compared to that of other anemias. The defect in red cell DNA synthesis is most often due to hypovitaminosis, specifically vitamin B12 deficiency or folate deficiency. Loss of micronutrients may also be a cause. Megaloblastic anemia not due to hypovitaminosis may be caused by antimetabolites that poison DNA production directly, such as some chemotherapeutic or antimicrobial agents (for example azathioprine or trimethoprim). The pathological state of megaloblastosis is characterized by many large immature and dysfunctional red blood cells (megaloblasts) in the bone marrow and also by hypersegmented neutrophils (defined as the presence of neutrophils with six or more lobes or the presence of more than 3% of neutrophils with at least five lobes). These hypersegmented neutrophils can be detected in the peripheral blood (using a diagnostic smear of a blood sample).

ChatGPT

  1. megaloblastic anemia

    Megaloblastic anemia is a blood disorder characterized by the presence of abnormally large, immature red blood cells (megaloblasts) in the bone marrow, which leads to a decreased number of healthy red blood cells circulating in the body. It is typically caused by a deficiency of either vitamin B-12 or folate, both of which are necessary for normal DNA synthesis and red blood cell division. This anemia can result in a variety of symptoms including fatigue, weakness, pale skin, digestive problems, and neurological issues.

Wikidata

  1. Megaloblastic anemia

    Megaloblastic anemia is an anemia that results from inhibition of DNA synthesis in red blood cell production. When DNA synthesis is impaired, the cell cycle cannot progress from the G2 growth stage to the mitosis stage. This leads to continuing cell growth without division, which presents as macrocytosis. Megaloblastic anemia has a rather slow onset, especially when compared to that of other anemias. The defect in red cell DNA synthesis is most often due to hypovitaminosis, specifically a deficiency of vitamin B12 and/or folic acid. Vitamin B12 deficiency alone will not cause the syndrome in the presence of sufficient folate, for the mechanism is loss of B12 dependent folate recycling, followed by folate-deficiency loss of nucleic acid synthesis, leading to defects in DNA synthesis. Folic acid supplementation in the absence of vitamin B12 prevents this type of anemia. Loss of micronutrients may also be a cause. Copper deficiency resulting from zinc excess from unusually high oral consumption of zinc containing denture fixation creams has been found to be a cause.

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Numerology

  1. Chaldean Numerology

    The numerical value of megaloblastic anemia in Chaldean Numerology is: 3

  2. Pythagorean Numerology

    The numerical value of megaloblastic anemia in Pythagorean Numerology is: 9

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"megaloblastic anemia." Definitions.net. STANDS4 LLC, 2024. Web. 4 Mar. 2024. <https://www.definitions.net/definition/megaloblastic+anemia>.

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