What does megaloblast mean?

Definitions for megaloblast
ˈmɛg ə ləˌblæstmega·loblast

This dictionary definitions page includes all the possible meanings, example usage and translations of the word megaloblast.

Princeton's WordNet

  1. megaloblastnoun

    abnormally large red blood cell present in pernicious anemia and folic acid deficiency


  1. megaloblastnoun

    An abnormally large red blood cell associated with pernicious anemia and with folic acid deficiency


  1. megaloblast

    A nucleated red blood cell (NRBC), also known by several other names, is a red blood cell that contains a cell nucleus. Almost all vertebrate organisms have hemoglobin-containing cells in their blood, and with the exception of mammals, all of these red blood cells are nucleated. In mammals, NRBCs occur in normal development as precursors to mature red blood cells in erythropoiesis, the process by which the body produces red blood cells. NRBCs are normally found in the bone marrow of humans of all ages and in the blood of fetuses and newborn infants. After infancy, RBCs normally contain a nucleus only during the very early stages of the cell's life, and the nucleus is ejected as a normal part of cellular differentiation before the cell is released into the bloodstream. Thus, if NRBCs are identified on an adult's complete blood count or peripheral blood smear, it suggests that there is a very high demand for the bone marrow to produce RBCs, and immature RBCs are being released into circulation. Possible pathologic causes include anemia, myelofibrosis, thalassemia, miliary tuberculosis, cancers involving bone marrow (myelomas, leukemias, lymphomas), and in chronic hypoxemia.


  1. megaloblast

    A megaloblast is an abnormally large, immature red blood cell found especially in people with certain types of anemia, such as pernicious anemia and megaloblastic anemia. This cell is characterized by the presence of a large nucleus relative to the size of the cell. The increased size is due to defective DNA synthesis, which slows down cell division and causes the cells to grow without dividing.


  1. Megaloblast

    A megaloblast is an unusually large erythroblast that can be associated with Vitamin B12 deficiency and/or folic acid deficiency. It is differentiated from a normoblast, which is a normally-sized erythroblast. This kind of anemia leads to macrocytes. The cause of this cellular gigantism is an impairment in DNA synthesis which delays nuclear maturation and cell division. Because RNA and cytoplasmic elements are synthesized at a constant rate despite the cells' impaired DNA synthesis, the cells show nuclear-cytoplasmic asynchrony.

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  1. Chaldean Numerology

    The numerical value of megaloblast in Chaldean Numerology is: 9

  2. Pythagorean Numerology

    The numerical value of megaloblast in Pythagorean Numerology is: 8


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"megaloblast." Definitions.net. STANDS4 LLC, 2024. Web. 2 Mar. 2024. <https://www.definitions.net/definition/megaloblast>.

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