What does megaloblastic anaemia mean?
Definitions for megaloblastic anaemia
mega·loblas·tic anaemi·a
This dictionary definitions page includes all the possible meanings, example usage and translations of the word megaloblastic anaemia.
Princeton's WordNet
megaloblastic anemia, megaloblastic anaemianoun
anemia characterized by many large immature and dysfunctional red blood cells (megaloblasts) in the bone marrow; associated with pernicious anemia
Wikipedia
megaloblastic anaemia
Megaloblastic anemia is a type of macrocytic anemia. An anemia is a red blood cell defect that can lead to an undersupply of oxygen. Megaloblastic anemia results from inhibition of DNA synthesis during red blood cell production. When DNA synthesis is impaired, the cell cycle cannot progress from the G2 growth stage to the mitosis (M) stage. This leads to continuing cell growth without division, which presents as macrocytosis. Megaloblastic anemia has a rather slow onset, especially when compared to that of other anemias. The defect in red cell DNA synthesis is most often due to hypovitaminosis, specifically vitamin B12 deficiency or folate deficiency. Loss of micronutrients may also be a cause. Megaloblastic anemia not due to hypovitaminosis may be caused by antimetabolites that poison DNA production directly, such as some chemotherapeutic or antimicrobial agents (for example azathioprine or trimethoprim). The pathological state of megaloblastosis is characterized by many large immature and dysfunctional red blood cells (megaloblasts) in the bone marrow and also by hypersegmented neutrophils (defined as the presence of neutrophils with six or more lobes or the presence of more than 3% of neutrophils with at least five lobes). These hypersegmented neutrophils can be detected in the peripheral blood (using a diagnostic smear of a blood sample).
Matched Categories
Numerology
Chaldean Numerology
The numerical value of megaloblastic anaemia in Chaldean Numerology is: 4
Pythagorean Numerology
The numerical value of megaloblastic anaemia in Pythagorean Numerology is: 1
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"megaloblastic anaemia." Definitions.net. STANDS4 LLC, 2024. Web. 10 May 2024. <https://www.definitions.net/definition/megaloblastic+anaemia>.
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