What does Diethylstilbestrol mean?

Definitions for Diethylstilbestrol
daɪˌɛθ əl stɪlˈbɛs trɔl, -trɒldi·ethyl·stilbe·strol

This dictionary definitions page includes all the possible meanings, example usage and translations of the word Diethylstilbestrol.

Princeton's WordNet

  1. diethylstilbestrol, diethylstilboestrol, stilbestrol, stilboestrol, DESnoun

    a potent estrogen used in medicine and in feed for livestock and poultry

Wiktionary

  1. diethylstilbestrolnoun

    An orally-active synthetic nonsteroidal oestrogen, first synthesized in 1938 and withdrawn in the 1970s on being identified as a teratogen.

Wikipedia

  1. Diethylstilbestrol

    Diethylstilbestrol (DES), also known as stilbestrol or stilboestrol, is a nonsteroidal estrogen medication, which is presently rarely used. In the past, it was widely used for a variety of indications, including pregnancy support for those with a history of recurrent miscarriage, hormone therapy for menopausal symptoms and estrogen deficiency, treatment of prostate cancer and breast cancer, and other uses. By 2007, it was only used in the treatment of prostate cancer and breast cancer. In 2011, Hoover and colleagues reported on adverse health outcomes linked to DES including infertility, miscarriage, ectopic pregnancy, preeclampsia, preterm birth, stillbirth, infant death, menopause prior to age 45, breast cancer, cervical cancer, and vaginal cancer. While most commonly taken by mouth, DES was available for use by other routes as well, for instance, vaginal, topical, and by injection. DES is an estrogen, or an agonist of the estrogen receptors, the biological target of estrogens like estradiol. It is a synthetic and nonsteroidal estrogen of the stilbestrol group, and differs from the natural estrogen estradiol in various ways. Compared to estradiol, DES has greatly improved bioavailability when taken by mouth, is more resistant to metabolism, and shows relatively increased effects in certain parts of the body like the liver and uterus. These differences result in DES having an increased risk of blood clots, cardiovascular issues, and certain other adverse effects.DES was discovered in 1938 and introduced for medical use in 1939. From about 1940 to 1971, the medication was given to pregnant women in the incorrect belief that it would reduce the risk of pregnancy complications and losses. In 1971, DES was shown to cause clear-cell carcinoma, a rare vaginal tumor, in those who had been exposed to this medication in utero. The United States Food and Drug Administration subsequently withdrew approval of DES as a treatment for pregnant women. Follow-up studies have indicated that DES also has the potential to cause a variety of significant adverse medical complications during the lifetimes of those exposed.The United States National Cancer Institute recommends children born to mothers who took DES to undergo special medical exams on a regular basis to screen for complications as a result of the medication. Individuals who were exposed to DES during their mothers' pregnancies are commonly referred to as "DES daughters" and "DES sons". Since the discovery of the toxic effects of DES, it has largely been discontinued and is now mostly no longer marketed.

ChatGPT

  1. diethylstilbestrol

    Diethylstilbestrol is a synthetic nonsteroidal estrogen that was formerly used to treat various medical conditions in both males and females. It was most commonly used in preventing miscarriages and premature births in pregnant women. However, it was found to increase the risk of cancer and was banned in many countries. Its use in animals intended for human consumption is also prohibited.

Wikidata

  1. Diethylstilbestrol

    Diethylstilbestrol is a synthetic nonsteroidal estrogen that was first synthesized in 1938. It is also classified as an endocrine disruptor. Human exposure to DES occurred through diverse sources, such as dietary ingestion from supplemented cattle feed and medical treatment for certain conditions, including breast and prostate cancers. From about 1940 to 1970, DES was given to pregnant women in the mistaken belief it would reduce the risk of pregnancy complications and losses. In 1971, DES was shown to cause a rare vaginal tumor in girls and women who had been exposed to this drug in utero. The United States Food and Drug Administration subsequently withdrew DES from use in pregnant women. Follow-up studies have indicated DES also has the potential to cause a variety of significant adverse medical complications during the lifetimes of those exposed. The United States National Cancer Institute recommends women born to mothers who took DES undergo special medical exams on a regular basis to screen for complications as a result of the drug. Individuals who were exposed to DES during their mothers' pregnancies are commonly referred to as "DES daughters" and "DES sons".

U.S. National Library of Medicine

  1. Diethylstilbestrol

    A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed)

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Numerology

  1. Chaldean Numerology

    The numerical value of Diethylstilbestrol in Chaldean Numerology is: 6

  2. Pythagorean Numerology

    The numerical value of Diethylstilbestrol in Pythagorean Numerology is: 9

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"Diethylstilbestrol." Definitions.net. STANDS4 LLC, 2024. Web. 26 Apr. 2024. <https://www.definitions.net/definition/Diethylstilbestrol>.

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