This page provides all possible meanings and translations of the word presenilins
U.S. National Library of MedicineRate this definition:(0.00 / 0 votes)
Integral membrane proteins and essential components of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PROTEIN precursors. Mutations of presenilins lead to presenile ALZHEIMER DISEASE with onset before age 65 years.
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