What does presenilin mean?
Definitions for presenilin
pre·se·nilin
This dictionary definitions page includes all the possible meanings, example usage and translations of the word presenilin.
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Wiktionary
presenilinnoun
Any of a class of transmembrane proteins
Wikidata
Presenilin
Presenilins are a family of related multi-pass transmembrane proteins that function as a part of the gamma-secretase intramembrane protease complex. They were first identified in screens for mutations causing early onset forms of familial Alzheimer's Disease by Peter St George-Hyslop at the Centre for Research in Neurodegenerative Diseases at the University of Toronto, and now also at the University of Cambridge. Vertebrates have two presenilin genes, called PSEN1 that encodes presenilin 1 and PSEN2 that codes for presenilin 2. Both genes show conservation between species, with little difference between rat and human presenilins. The nematode worm C. elegans has two genes that resemble the presenilins and appear to be functionally similar, sel-12 and hop-1. Presenilins undergo cleavage in an alpha helical region of one of the cytoplasmic loops to produce a larger N-terminal and a smaller C-terminal fragment that together form part of the functional protein. Cleavage of presenilin 1 can be prevented by a mutation that causes the loss of exon 9, and results in loss of function. Presenilins play a key role in the modulation of intracellular Ca2+ involved in presynaptic neurotransmitter release and long-term potentiation induction.
Numerology
Chaldean Numerology
The numerical value of presenilin in Chaldean Numerology is: 2
Pythagorean Numerology
The numerical value of presenilin in Pythagorean Numerology is: 4
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"presenilin." Definitions.net. STANDS4 LLC, 2024. Web. 25 Apr. 2024. <https://www.definitions.net/definition/presenilin>.
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