Definitions for presenilin-2

This page provides all possible meanings and translations of the word presenilin-2

U.S. National Library of Medicine

  1. Presenilin-2

    Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PROTEIN precursors. PSEN2 mutations cause ALZHEIMER DISEASE type 4.

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