Definitions for raclopride
raclo·pride

WiktionaryRate this definition:0.0 / 0 votes

1. raclopridenoun

   A synthetic compound that acts as an antagonist on D2 dopamine receptors.

WikipediaRate this definition:0.0 / 0 votes

1. Raclopride

   Raclopride is a typical antipsychotic. It acts as a selective antagonist on D2 dopamine receptors. It has been used in trials studying Parkinson Disease.Its selectivity to the cerebral D2 receptors is characterized by its respective Ki-values, which are as follows: 1.8, 3.5, 2400 and 18000 nM for D2, D3, D4 and D1 receptors respectively. It can be radiolabelled with radioisotopes, e.g. 3H or 11C and used as a tracer for in vitro imaging (autoradiography) as well as in vivo imaging positron emission tomography (PET). Images obtained by cerebral PET scanning (e.g. PET/CT or PET/MRI) allow the non-invasive assessment of the binding capacity of the cerebral D2 dopamine receptor, which can be useful for the diagnosis of movement disorders. In particular, cerebral D2 receptor binding as measured by carbon-11-raclopride (11C-raclopride) has shown to reflect disease severity of Huntington's disease, a genetic disease characterized by selective degeneration of cerebral D2 receptors.Other studies have investigated the relationship of D2 receptor binding capacity and personality disorders. One study found decreased binding in the detachment personality trait. Radiolabelled raclopride is also commonly used to determine the efficacy and neurotoxicity of dopaminergic drugs.

FreebaseRate this definition:0.0 / 0 votes

1. Raclopride

   Raclopride is a synthetic compound that acts as an antagonist on D2 dopamine receptors. It can be radiolabelled with the carbon-11 radioisotope and used in positron emission tomography scanning to assess the degree of dopamine binding to the D2 Dopamine receptor. For example, one study found decreasing binding with the personality trait detachment. Radiolabelled raclopride is also commonly used to determine the efficacy and neurotoxicity of dopaminergic drugs.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Raclopride

   A substituted benzamide that has antipsychotic properties. It is a dopamine D2 receptor (see RECEPTORS, DOPAMINE D2) antagonist.

Anagrams for raclopride »

1. precordial

How to pronounce raclopride?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say raclopride in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of raclopride in Chaldean Numerology is: 9

2. Pythagorean Numerology

   The numerical value of raclopride in Pythagorean Numerology is: 2