What does epsin mean?
Definitions for epsin
epsin
This dictionary definitions page includes all the possible meanings, example usage and translations of the word epsin.
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Wiktionary
epsinnoun
A protein that has a function in maintaining cell membrane curvature
Wikipedia
Epsin
Epsins are a family of highly conserved membrane proteins that are important in creating membrane curvature. Epsins contribute to membrane deformations like endocytosis, and block vesicle formation during mitosis.
Wikidata
Epsin
Epsins are the family of membrane proteins that are important in creating the needed membrane curvature. Epsins contribute to various needed membrane deformations like endocytosis and block vesicle formation during mitosis. Epsins have many different domains to interact with various proteins related to endocytosis. At its N-terminus is an ENTH domain that binds Phosphatidylinositol-bisphosphate, meaning that it binds a lipid of biological membranes. It has also been postulated that this is a site for cargo-binding. In the middle of the epsin sequence are two UIMs. The C-terminus contains multiple binding sites, for example for clathrin and AP2 adaptors. As such, Epsins are able to bind to a membrane with a specific cargo and connect it with the endocytosis machinery, so one may understand Epsin as something like a Swiss army knife for endocytosis. They may be the major membrane curvature driving proteins in many clathrin-coated vesicle budding events. Epsin 4, which encodes the protein Enthoprotin, now known as Clathrin Interactor 1, has been shown to be involved in the genetic susceptibility to schizophrenia in four independent studies. A genetic abnormality in CLINT1 is assumed to change the way internalisation of neurotransmitter receptors occurs in the brains of people with schizophrenia.
Anagrams for epsin »
penis
pines
snipe
spine
Numerology
Chaldean Numerology
The numerical value of epsin in Chaldean Numerology is: 4
Pythagorean Numerology
The numerical value of epsin in Pythagorean Numerology is: 9
Translations for epsin
From our Multilingual Translation Dictionary
- EpsinSpanish
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"epsin." Definitions.net. STANDS4 LLC, 2024. Web. 26 Apr. 2024. <https://www.definitions.net/definition/epsin>.
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