Definitions for c1-inhibitor
c1-inhibitor

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1. C1-inhibitor

   C1-inhibitor (C1-inh, C1 esterase inhibitor) is a protease inhibitor belonging to the serpin superfamily. Its main function is the inhibition of the complement system to prevent spontaneous activation but also as the major regulator of the contact system. C1-inhibitor is an acute-phase protein that circulates in blood at levels of around 0.25 g/L. The levels rise ~2-fold during inflammation. C1-inhibitor irreversibly binds to and inactivates C1r and C1s proteases in the C1 complex of classical pathway of complement. MASP-1 and MASP-2 proteases in MBL complexes of the lectin pathway are also inactivated. This way, C1-inhibitor prevents the proteolytic cleavage of later complement components C4 and C2 by C1 and MBL. Although named after its complement inhibitory activity, C1-inhibitor also inhibits proteases of the fibrinolytic, clotting, and kinin pathways. Note that C1-inhibitor is the most important physiological inhibitor of plasma kallikrein, fXIa, and fXIIa.

How to pronounce c1-inhibitor?

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Numerology

1. Chaldean Numerology

   The numerical value of c1-inhibitor in Chaldean Numerology is: 4

2. Pythagorean Numerology

   The numerical value of c1-inhibitor in Pythagorean Numerology is: 8

Examples of c1-inhibitor in a Sentence

1. Spencer Richlin:

   For example, take a woman with hypertension, she may normally be on an ACE inhibitor but during pregnancy her doctor should switch her to a beta blocker.

2. Bill Sasiela:

   This is the first time a PCSK9 inhibitor has shown in a clinical study that it reduced the frequency of apheresis therapy, an invasive, difficult to access, time-consuming and expensive treatment for some of the most difficult-to-treat patients.

3. Jeff Nassof:

   Debt financing is cheap, so that's not really any inhibitor to financing a big deal.

4. Linn Huang:

   While the products themselves are more iterative than revolutionary — same basic design — Apple's strategy in raising the spec ceiling should prove to be a prudent one, since 2015, the entire all-in-one category has contracted each year. A continued shift toward mobility has been a primary inhibitor for this form factor, but options and economics play a large role as well.

5. Elias Zerhouni:

   Immuno-oncology is just at the beginning of its development, frankly, I think it won't be enough to just remove a checkpoint inhibitor because it is also important to activate the immune system.

References

1. ^ Wikipedia
   https://en.wikipedia.org/wiki/C1-Inhibitor