Definitions for tyrosine kinase inhibitor
ty·ro·sine ki·nase in·hibitor

Princeton's WordNetRate this definition:0.0 / 0 votes

1. tyrosine kinase inhibitornoun

   a drug used in cases of chronic myeloid leukemia

WikipediaRate this definition:0.0 / 0 votes

1. Tyrosine kinase inhibitor

   A tyrosine kinase inhibitor (TKI) is a pharmaceutical drug that inhibits tyrosine kinases. Tyrosine kinases are enzymes responsible for the activation of many proteins by signal transduction cascades. The proteins are activated by adding a phosphate group to the protein (phosphorylation), a step that TKIs inhibit. TKIs are typically used as anticancer drugs. For example, they have substantially improved outcomes in chronic myelogenous leukemia. They have also been used to treat other diseases, such as idiopathic pulmonary fibrosis. They are also called tyrphostins, the short name for "tyrosine phosphorylation inhibitor", originally coined in a 1988 publication, which was the first description of compounds inhibiting the catalytic activity of the epidermal growth factor receptor (EGFR). The 1988 study was the first demonstration of a systematic search and discovery of small-molecular-weight inhibitors of tyrosine phosphorylation, which do not inhibit protein kinases that phosphorylate serine or threonine residues and can discriminate between the kinase domains of the EGFR and that of the insulin receptor. It was further shown that in spite of the conservation of the tyrosine-kinase domains one can design and synthesize tyrphostins that discriminate between even closely related protein tyrosine kinases such as EGFR and its close relative HER2.

ChatGPTRate this definition:0.0 / 0 votes

1. tyrosine kinase inhibitor

   A tyrosine kinase inhibitor is a type of pharmaceutical drug that inhibits or blocks the enzymatic activity of a protein known as tyrosine kinase. This enzyme plays a key role in several biological processes, including cell division, growth, and even cell death. When the activity of tyrosine kinase is unregulated, it can lead to various types of cancer. The inhibitor works by disrupting the signaling pathways that lead to cell proliferation and survival, thereby reducing the progression of cancerous cells. These inhibitors are used in the treatment of various types of cancers, including leukemia, breast cancer, lung cancer, and more.

WikidataRate this definition:0.0 / 0 votes

1. Tyrosine Kinase Inhibitor

   Substances that inhibit tyrosine kinase enzymes, involved with the transduction and processing of many extracellular and intracellular signals including cell proliferation. They have numerous applications in the prevention and treatment of cancer. (NCI)

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1. • Medicine

How to pronounce tyrosine kinase inhibitor?

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Numerology

1. Chaldean Numerology

   The numerical value of tyrosine kinase inhibitor in Chaldean Numerology is: 1

2. Pythagorean Numerology

   The numerical value of tyrosine kinase inhibitor in Pythagorean Numerology is: 9

References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=tyrosine kinase inhibitor
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Tyrosine_Kinase_Inhibitor
3. ^ ChatGPT
   https://chat.openai.com
4. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=tyrosine kinase inhibitor