What does tyrosine kinase inhibitor mean?
Definitions for tyrosine kinase inhibitor
ty·ro·sine ki·nase in·hibitor
This dictionary definitions page includes all the possible meanings, example usage and translations of the word tyrosine kinase inhibitor.
Princeton's WordNet
tyrosine kinase inhibitornoun
a drug used in cases of chronic myeloid leukemia
Wikipedia
Tyrosine kinase inhibitor
A tyrosine kinase inhibitor (TKI) is a pharmaceutical drug that inhibits tyrosine kinases. Tyrosine kinases are enzymes responsible for the activation of many proteins by signal transduction cascades. The proteins are activated by adding a phosphate group to the protein (phosphorylation), a step that TKIs inhibit. TKIs are typically used as anticancer drugs. For example, they have substantially improved outcomes in chronic myelogenous leukemia. They have also been used to treat other diseases, such as idiopathic pulmonary fibrosis. They are also called tyrphostins, the short name for "tyrosine phosphorylation inhibitor", originally coined in a 1988 publication, which was the first description of compounds inhibiting the catalytic activity of the epidermal growth factor receptor (EGFR). The 1988 study was the first demonstration of a systematic search and discovery of small-molecular-weight inhibitors of tyrosine phosphorylation, which do not inhibit protein kinases that phosphorylate serine or threonine residues and can discriminate between the kinase domains of the EGFR and that of the insulin receptor. It was further shown that in spite of the conservation of the tyrosine-kinase domains one can design and synthesize tyrphostins that discriminate between even closely related protein tyrosine kinases such as EGFR and its close relative HER2.
Wikidata
Tyrosine Kinase Inhibitor
Substances that inhibit tyrosine kinase enzymes, involved with the transduction and processing of many extracellular and intracellular signals including cell proliferation. They have numerous applications in the prevention and treatment of cancer. (NCI)
Matched Categories
Numerology
Chaldean Numerology
The numerical value of tyrosine kinase inhibitor in Chaldean Numerology is: 1
Pythagorean Numerology
The numerical value of tyrosine kinase inhibitor in Pythagorean Numerology is: 9
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"tyrosine kinase inhibitor." Definitions.net. STANDS4 LLC, 2024. Web. 11 May 2024. <https://www.definitions.net/definition/tyrosine+kinase+inhibitor>.
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