What does zymogen mean?

Definitions for zymogen
ˈzaɪ mə dʒən, -ˌdʒɛnzy·mo·gen

This dictionary definitions page includes all the possible meanings, example usage and translations of the word zymogen.

Princeton's WordNet

  1. proenzyme, zymogennoun

    any of a group of compounds that are inactive precursors of enzymes and require some change (such as the hydrolysis of a fragment that masks an active enzyme) to become active

Wiktionary

  1. zymogennoun

    A proenzyme, or enzyme precursor, which requires a biochemical change (i.e. hydrolysis) to become an active form of the enzyme.

Wikipedia

  1. Zymogen

    In biochemistry, a zymogen (), also called a proenzyme (), is an inactive precursor of an enzyme. A zymogen requires a biochemical change (such as a hydrolysis reaction revealing the active site, or changing the configuration to reveal the active site) for it to become an active enzyme. The biochemical change usually occurs in Golgi bodies, where a specific part of the precursor enzyme is cleaved in order to activate it. The inactivating piece which is cleaved off can be a peptide unit, or can be independently-folding domains comprising more than 100 residues. Although they limit the enzyme's ability, these N-terminal extensions of the enzyme or a “prosegment” often aid in the stabilization and folding of the enzyme they inhibit.The pancreas secretes zymogens partly to prevent the enzymes from digesting proteins in the cells in which they are synthesised. Enzymes like pepsin are created in the form of pepsinogen, an inactive zymogen. Pepsinogen is activated when chief cells release it into the gastric acid, whose hydrochloric acid partially activates it. Another partially inactivated pepsinogen completes the activation by removing the peptide, turning the pepsinogen into pepsin. Accidental activation of zymogens can happen when the secretion duct in the pancreas is blocked by a gallstone, resulting in acute pancreatitis.Fungi also secrete digestive enzymes into the environment as zymogens. The external environment has a different pH than inside the fungal cell and this changes the zymogen's structure into an active enzyme.Another way that enzymes can exist in inactive forms and later be converted to active forms is by activating only when a cofactor, called a coenzyme, is bound. In this system, the inactive form (the apoenzyme) becomes the active form (the holoenzyme) when the coenzyme binds. In the duodenum, the pancreatic zymogens, trypsinogen, chymotrypsinogen, proelastase and procarboxypeptidase are converted into active enzymes by enteropeptidase and trypsin. Chymotrypsinogen, is single polypeptide chain of 245 amino acids residues, is converted to alpha-chymotrypsin, which has three polypeptide chains linked by two of the five disulfide bond present in the primary structure of chymotrypsinogen.

ChatGPT

  1. zymogen

    A zymogen is an inactive precursor molecule that is converted into an active enzyme by undergoing a biochemical change, often involving the removal or modification of a protein segment. This conversion typically occurs in response to a specific biological signal or environmental condition. Zymogens are part of the body's way of controlling its biochemical reactions.

Webster Dictionary

  1. Zymogennoun

    a mother substance, or antecedent, of an enzyme or chemical ferment; -- applied to such substances as, not being themselves actual ferments, may by internal changes give rise to a ferment

  2. Etymology: [Zyme + -gen.]

Wikidata

  1. Zymogen

    A zymogen is an inactive enzyme precursor. A zymogen requires a biochemical change for it to become an active enzyme. The biochemical change usually occurs in a lysosome where a specific part of the precursor enzyme is cleaved in order to activate it. The inactivating piece which is cleaved off can be a peptide unit, or can be independently folding domains comprising more than 100 residues. Although they limit the enzyme's ability, these n-terminal extensions of the enzyme or a “prosegment” often aid in the stabilizing and folding of the enzyme they inhibit. The pancreas secretes zymogens partly to prevent the enzymes from digesting proteins in the cells in which they are synthesised. Enzymes like pepsin are created in the form of pepsinogen, an inactive zymogen. Pepsinogen is activated when Chief cells release it into HCl which partially activates it. Another partially activated pepsinogen completes the activation by removing the peptide turning the pepsinogen into pepsin. Accidental activation of zymogens can happen when the secretion duct in the pancreas is blocked by a gallstone resulting in acute pancreatitis.

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Numerology

  1. Chaldean Numerology

    The numerical value of zymogen in Chaldean Numerology is: 5

  2. Pythagorean Numerology

    The numerical value of zymogen in Pythagorean Numerology is: 6

Popularity rank by frequency of use

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"zymogen." Definitions.net. STANDS4 LLC, 2024. Web. 21 Jul 2024. <https://www.definitions.net/definition/zymogen>.

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