What does xorphanol mean?

Definitions for xorphanol
xor·phanol

This dictionary definitions page includes all the possible meanings, example usage and translations of the word xorphanol.

Wiktionary

  1. xorphanolnoun

    An opioid analgesic of the morphinan family.

Wikipedia

  1. Xorphanol

    Xorphanol (INN) (developmental code name TR-5379 or TR-5379M), also known as xorphanol mesylate (USAN), is an opioid analgesic of the morphinan family that was never marketed.Xorphanol is a mixed agonist–antagonist of opioid receptors, acting preferentially as a high-efficacy partial agonist/near-full agonist of the κ-opioid receptor (Ki = 0.4 nM; EC50 = 3.3 nM; Imax = 49%; IA = 0.84) and to a lesser extent as a partial agonist of the μ-opioid receptor (Ki = 0.25 nM; IC50 = 3.4 nM; Imax = 29%) with lower relative intrinsic activity and marked antagonistic potential (including the ability to antagonize morphine-induced effects and induce opioid withdrawal in opioid-dependent individuals). The drug has also been found to act as an agonist of the δ-opioid receptor (Ki = 1.0 nM; IC50 = 8 nM; Imax = 76%).Xorphanol produces potent analgesia, and was originally claimed to possess a minimal potential for dependence or abuse. Moreover, side effects in animal studies were relatively mild, with only sedation and nausea being prominent, although it also produced convulsions at the highest dose tested. However, human trials revealed additional side effects such as headaches and euphoria, and this was the subject of a lawsuit between the drug's inventors and the company to which they had licensed the marketing rights, which claimed that these side effects had not been revealed to them during the license negotiations. As a result of this dispute, the drug was never marketed commercially.

Wikidata

  1. Xorphanol

    Xorphanol is an opioid analgesic from the morphinan family of drugs. It is a mixed agonist–antagonist at the μ-opioid receptor and produces potent analgesic effects with little potential for dependence or abuse. Side effects in animal studies were relatively mild, with only sedation and nausea being prominent, although it also produced convulsions at the highest dose tested. However human trials revealed additional side effects such as headaches and euphoria, and this was the subject of a lawsuit between the drug's inventors and the company to which they had licensed the marketing rights, which claimed that these side effects had not been revealed to them during the license negotiations. This dispute resulted in the drug never being marketed commercially, although it is still used in scientific research.

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Numerology

  1. Chaldean Numerology

    The numerical value of xorphanol in Chaldean Numerology is: 7

  2. Pythagorean Numerology

    The numerical value of xorphanol in Pythagorean Numerology is: 6

Translation

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"xorphanol." Definitions.net. STANDS4 LLC, 2024. Web. 21 Jul 2024. <https://www.definitions.net/definition/xorphanol>.

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