Definitions for vioxx
vioxx

Princeton's WordNetRate this definition:0.0 / 0 votes

1. rofecoxib, Vioxxnoun

   a Cox-2 inhibitor (trade name Vioxx) that relieves pain and inflammation without harming the digestive tract; voluntarily withdrawn from the market in 2004

WikipediaRate this definition:0.0 / 0 votes

1. vioxx

   Rofecoxib is a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID). It was marketed by Merck & Co. to treat osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, acute pain conditions, migraine, and dysmenorrhea. Rofecoxib was approved in the US by the US Food and Drug Administration (FDA) in May 1999, and was marketed under the brand names Vioxx, Ceoxx, and Ceeoxx. Rofecoxib was available by prescription in both tablet-form and as an oral suspension.Rofecoxib gained widespread use among physicians treating patients with arthritis and other conditions causing chronic or acute pain. Worldwide, over 80 million people were prescribed rofecoxib at some time.In September 2004, Merck voluntarily withdrew rofecoxib from the market because of concerns about increased risk of heart attack and stroke associated with long-term, high-dosage use. Merck withdrew the drug after disclosures that it withheld information about rofecoxib's risks from doctors and patients for over five years, allegedly resulting in between 88,000 and 140,000 cases of serious heart disease. Rofecoxib was one of the most widely used drugs ever to be withdrawn from the market. In the year before withdrawal, Merck had sales revenue of US$2.5 billion from Vioxx.In 2005 the FDA issued a memo concluding that risks for serious cardiovascular (CV) events seem to be as great for non-selective NSAIDs as for COX-2 selective agents such as rofecoxib, according to long-term controlled clinical trials. Based on data up to 2015, the FDA reasserted the likelihood of an increased risk of serious adverse cardiovascular events from COX-2 selective and non-selective NSAIDs, dependent on dose and duration.In November 2017, Massachusetts-based Tremeau Pharmaceuticals announced its plan to return rofecoxib (TRM-201) to market as a treatment for hemophilic arthropathy (HA). Tremeau announced that the FDA had granted an orphan designation for TRM-201 (rofecoxib) for the treatment of HA, and that they had received FDA feedback on their development plan. HA is a degenerative joint disease caused by recurrent intra-articular bleeding. It is the largest cause of morbidity in patients with hemophilia and has no currently approved treatment options in the United States. Traditional NSAIDs are avoided in this population due to their effects on platelet aggregation and risk of gastrointestinal ulcers, and high potency opioids are the current standard of care in treating HA.

ChatGPTRate this definition:0.0 / 0 votes

1. vioxx

   Vioxx is a nonsteroidal anti-inflammatory drug (NSAID) that was used to reduce pain, inflammation, and stiffness caused by osteoarthritis, rheumatoid arthritis, and certain forms of juvenile rheumatoid arthritis in adults and children. It was also used to manage acute pain in adults and to treat menstrual pain. The drug was produced by Merck & Co but was withdrawn from the market globally in 2004 after it was found to increase the risk of heart attack and stroke.

How to pronounce vioxx?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say vioxx in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of vioxx in Chaldean Numerology is: 6

2. Pythagorean Numerology

   The numerical value of vioxx in Pythagorean Numerology is: 4

Popularity rank by frequency of use

References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=vioxx
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Vioxx
3. ^ ChatGPT
   https://chat.openai.com