Definitions for urokinase
ˌyʊər əˈkaɪ neɪs, -neɪzuroki·nase

Princeton's WordNetRate this definition:0.0 / 0 votes

1. plasminogen activator, urokinasenoun

   protease produced in the kidney that converts plasminogen to plasmin and so initiates fibrinolysis

WiktionaryRate this definition:0.0 / 0 votes

1. urokinasenoun

   An enzyme, found in the urine, which converts plasminogen to plasmin, and is used in the treatment of deep vein thrombosis.

WikipediaRate this definition:0.0 / 0 votes

1. Urokinase

   Urokinase, also known as urokinase-type plasminogen activator (uPA), is a serine protease present in humans and other animals. The human urokinase protein was discovered, but not named, by McFarlane and Pilling in 1947. Urokinase was originally isolated from human urine, and it is also present in the blood and in the extracellular matrix of many tissues. The primary physiological substrate of this enzyme is plasminogen, which is an inactive form (zymogen) of the serine protease plasmin. Activation of plasmin triggers a proteolytic cascade that, depending on the physiological environment, participates in thrombolysis or extracellular matrix degradation. This cascade had been involved in vascular diseases and cancer progression.Urokinase is encoded in humans by the PLAU gene, which stands for "plasminogen activator, urokinase". The same symbol represents the gene in other animal species.

ChatGPTRate this definition:0.0 / 0 votes

1. urokinase

   Urokinase is a naturally occurring enzyme in humans that catalyzes the conversion of plasminogen to plasmin, an enzyme responsible for the dissolution of blood clots. It can be used therapeutically in medicine, as injections, to dissolve clots in the treatment of heart attacks, strokes, and severe deep vein thrombosis.

WikidataRate this definition:0.0 / 0 votes

1. Urokinase

   Urokinase, also called urokinase-type plasminogen activator, is a serine protease. It was first discovered in 1947 by McFarlane. Urokinase was originally isolated from human urine, but is present in several physiological locations, such as blood stream and the extracellular matrix. The primary physiological substrate is plasminogen, which is an inactive form of the serine protease plasmin. Activation of plasmin triggers a proteolysis cascade that, depending on the physiological environment, participates in thrombolysis or extracellular matrix degradation. This links urokinase to vascular diseases and cancer.

Matched Categories

1. • Protease

How to pronounce urokinase?

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Numerology

1. Chaldean Numerology

   The numerical value of urokinase in Chaldean Numerology is: 5

2. Pythagorean Numerology

   The numerical value of urokinase in Pythagorean Numerology is: 5

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References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=urokinase
2. ^ Wiktionary
   https://en.wiktionary.org/wiki/Urokinase
3. ^ Wikipedia
   https://en.wikipedia.org/wiki/Urokinase
4. ^ ChatGPT
   https://chat.openai.com
5. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=urokinase