What does tremelimumab mean?

Definitions for tremelimumab

Here are all the possible meanings and translations of the word tremelimumab.


  1. tremelimumab(Noun)

    A human monoclonal antibody that binds to the protein CTLA-4, under investigation to treat various kinds of tumour.


  1. Tremelimumab

    Tremelimumab is a fully human IgG2 monoclonal antibody produced by Pfizer, undergoing human trials for the treatment of cancer. Cytotoxic T lymphocytes can recognize and destroy cancer cells. However, there is also an inhibitory mechanism that interrupts this destruction. Tremelimumab turns off this inhibitory mechanism and allows CTLs to continue to destroy the cancer cells. Tremelimumab binds to the protein CTLA-4, which is expressed on the surface of activated T lymphocytes and inhibits the killing of cancer cells. Tremelimumab blocks the binding of the antigen-presenting cell ligands B7.1 and B7.2 to CTLA-4, resulting in inhibition of B7-CTLA-4-mediated downregulation of T-cell activation; subsequently, B7.1 or B7.2 may interact with another T-cell surface receptor protein, CD28, resulting in a B7-CD28-mediated T-cell activation unopposed by B7-CTLA-4-mediated inhibition. Tremelimumab stimulates patients’ immune systems to attack their tumors. It has induced durable tumor responses in patients with metastatic melanoma in Phase 1 and Phase 2 clinical studies. On April 2, 2008, Pfizer announced that it has discontinued a Phase III clinical trial for patients with advanced melanoma after the review of interim data showed that the trial would not demonstrate superiority to standard chemotherapy. Studies for other tumors are planned as of October 2009, namely for prostate cancer and bladder cancer.

How to pronounce tremelimumab?

  1. Alex
    US English

How to say tremelimumab in sign language?

  1. tremelimumab


  1. Chaldean Numerology

    The numerical value of tremelimumab in Chaldean Numerology is: 5

  2. Pythagorean Numerology

    The numerical value of tremelimumab in Pythagorean Numerology is: 6

Images & Illustrations of tremelimumab

  1. tremelimumab


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    "tremelimumab." Definitions.net. STANDS4 LLC, 2020. Web. 20 Sep. 2020. <https://www.definitions.net/definition/tremelimumab>.

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