Definitions for transketolase
trans·ke·to·lase

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1. transketolase(Noun)

   An enzyme of both the pentose phosphate pathway in animals and the Calvin cycle of photosynthesis, which catalyzes two important reactions.

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1. Transketolase

   Transketolase is an enzyme of both the pentose phosphate pathway in all organisms and the Calvin cycle of photosynthesis. It catalyzes two important reactions, which operate in opposite directions in these two pathways. In the first reaction of the non-oxidative pentose phosphate pathway, the cofactor thiamine diphosphate accepts a 2-carbon fragment from a 5-carbon ketose, then transfers this fragment to a 5-carbon aldose to form a 7-carbon ketose. The abstraction of two carbons from D-xylulose-5-P yields the 3-carbon aldose glyceraldehyde-3-P. In the Calvin cycle, transketolase catalyzes the reverse reaction, the conversion of sedoheptulose-7-P and glyceraldehyde-3-P to pentoses, the aldose D-ribose-5-P and the ketose D-xylulose-5-P. The second reaction catalyzed by transketolase in the pentose phosphate pathway involves the same thiamine diphosphate-mediated transfer of a 2-carbon fragment from D-xylulose-5-P to the aldose erythrose-4-phosphate, affording fructose 6-phosphate and glyceraldehyde-3-P. Again, in the Calvin cycle exactly the same reaction occurs, but in the opposite direction. Moreover, in the Calvin cycle this is the first reaction catalyzed by transketolase, rather than the second.

U.S. National Library of Medicine(0.00 / 0 votes)Rate this definition:

1. Transketolase

   An enzyme of the transferase class that catalyzes the conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate to D-ribose 5-phosphate and D-xylulose 5-phosphate in the PENTOSE PHOSPHATE PATHWAY. (Dorland, 27th ed) EC 2.2.1.1.

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Numerology

1. Chaldean Numerology

   The numerical value of transketolase in Chaldean Numerology is: 9

2. Pythagorean Numerology

   The numerical value of transketolase in Pythagorean Numerology is: 7

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