Definitions for tolvaptan
tolvap·tan

WiktionaryRate this definition:0.0 / 0 votes

1. tolvaptannoun

   A certain vaptan drug used to treat hyponatremia and potentially polycystic kidney disease.

WikipediaRate this definition:0.0 / 0 votes

1. Tolvaptan

   Tolvaptan, sold under the brand name Samsca among others, is an aquaretic drug that functions as a selective, competitive vasopressin receptor 2 (V2) antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH). Tolvaptan was approved by the U.S. Food and Drug Administration (FDA) on May 19, 2009, and is sold by Otsuka Pharmaceutical Co. under the trade name Samsca. Tolvaptan, as Jynarque, was granted approval for medical use in the United States in April 2018.The U.S. Food and Drug Administration (FDA) granted tolvaptan a fast track designation for clinical trials investigating its use for the treatment of polycystic kidney disease. The FDA granted Jynarque an orphan drug designation in April 2012, for the treatment of autosomal dominant polycystic kidney disease.Tolvaptan is available as a generic medication.

WikidataRate this definition:0.0 / 0 votes

1. Tolvaptan

   Tolvaptan, also known as OPC-41061, is a selective, competitive vasopressin receptor 2 antagonist used to treat hyponatremia associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone. Tolvaptan was approved by the U.S. Food and Drug Administration on May 19, 2009, and is sold by Otsuka Pharmaceutical Co. under the trade name Samsca and in India is manufactured & sold by MSN laboratories Ltd. under the trade name Tolsama & Tolvat. Tolvaptan is also in fast-track clinical trials for polycystic kidney disease. In a 2004 trial, tolvaptan, when administered with traditional diuretics, was noted to increase excretion of excess fluids and improve blood sodium levels in patients with heart failure without producing side effects such as hypotension or hypokalemia and without having an adverse effect on kidney function. In a recently published trial the study met its primary and secondary end points. Tolvaptan, when given at an average dose of 95 mg per day over a 3-year period, slowed the usual increase in kidney volume by 50% compared to placebo and reduced the decline in kidney function when compared with that of placebo-treated patients by approximately 30%

How to pronounce tolvaptan?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say tolvaptan in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of tolvaptan in Chaldean Numerology is: 3

2. Pythagorean Numerology

   The numerical value of tolvaptan in Pythagorean Numerology is: 4

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Tolvaptan
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Tolvaptan
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=tolvaptan