What does tienilic acid mean?

Definitions for tienilic acid
tie·nil·ic acid

Here are all the possible meanings and translations of the word tienilic acid.

Wiktionary

  1. tienilic acidnoun

    A diuretic drug with uricosuric action, formerly marketed for the treatment of hypertension.

Freebase

  1. Tienilic acid

    Tienilic acid or ticrynafen is a loop diuretic drug with uric acid-lowering action, formerly marketed for the treatment of hypertension. It was approved by FDA on May 2, 1979, and withdrawn in 1982, after case reports in the United States indicated a link between the use of ticrynafen and hepatitis. Criminal charges were brought against SmithKline executives with regard to hiding data related to toxicity while gaining FDA approval. The company pleaded guilty to 14 counts of failure to report adverse reactions and 20 counts of selling a misbranded drug. Tienilic acid was found to act as a suicide substrate at the cytochrome P450 enzymes involved in drug metabolism. Unfortunately, the metabolic reaction carried out by these enzymes converted tienilic acid to a thiophene sulfoxide which proved highly electrophilic. This encouraged a Michael reaction leading to alkylation of a thiol group in the enzyme's active site. Loss of water from the thiophene sulfoxide restored the thiophene ring and resulted in tienilic acid being covalently linked to the enzyme, thus inhibiting the enzyme irreversibly. The above explanation is a hypothesis. It is still not known if the reactive intermediate which inactivates the CYP2C9 is the thiophene sulfoxide or the thiophene epoxide. The target on the protein is also not known. However tienilic acid is a good mechanism based inhibitor of CYP2C9 and seems to inactivate it stoichiometrically. Progress in proteomics may one day give the answer.

How to pronounce tienilic acid?

  1. Alex
    US English
    Daniel
    British
    Karen
    Australian
    Veena
    Indian

How to say tienilic acid in sign language?

Numerology

  1. Chaldean Numerology

    The numerical value of tienilic acid in Chaldean Numerology is: 5

  2. Pythagorean Numerology

    The numerical value of tienilic acid in Pythagorean Numerology is: 8

Images & Illustrations of tienilic acid

  1. tienilic acid

Translation

Find a translation for the tienilic acid definition in other languages:

Select another language:

  • - Select -
  • 简体中文 (Chinese - Simplified)
  • 繁體中文 (Chinese - Traditional)
  • Español (Spanish)
  • Esperanto (Esperanto)
  • 日本語 (Japanese)
  • Português (Portuguese)
  • Deutsch (German)
  • العربية (Arabic)
  • Français (French)
  • Русский (Russian)
  • ಕನ್ನಡ (Kannada)
  • 한국어 (Korean)
  • עברית (Hebrew)
  • Gaeilge (Irish)
  • Українська (Ukrainian)
  • اردو (Urdu)
  • Magyar (Hungarian)
  • मानक हिन्दी (Hindi)
  • Indonesia (Indonesian)
  • Italiano (Italian)
  • தமிழ் (Tamil)
  • Türkçe (Turkish)
  • తెలుగు (Telugu)
  • ภาษาไทย (Thai)
  • Tiếng Việt (Vietnamese)
  • Čeština (Czech)
  • Polski (Polish)
  • Bahasa Indonesia (Indonesian)
  • Românește (Romanian)
  • Nederlands (Dutch)
  • Ελληνικά (Greek)
  • Latinum (Latin)
  • Svenska (Swedish)
  • Dansk (Danish)
  • Suomi (Finnish)
  • فارسی (Persian)
  • ייִדיש (Yiddish)
  • հայերեն (Armenian)
  • Norsk (Norwegian)
  • English (English)

Word of the Day

Would you like us to send you a FREE new word definition delivered to your inbox daily?

Please enter your email address:


Discuss these tienilic acid definitions with the community:

0 Comments

    Citation

    Use the citation below to add this definition to your bibliography:

    Style:MLAChicagoAPA

    "tienilic acid." Definitions.net. STANDS4 LLC, 2021. Web. 24 Jul 2021. <https://www.definitions.net/definition/tienilic+acid>.

    Are we missing a good definition for tienilic acid? Don't keep it to yourself...

    Browse Definitions.net

    Free, no signup required:

    Add to Chrome

    Get instant definitions for any word that hits you anywhere on the web!

    Free, no signup required:

    Add to Firefox

    Get instant definitions for any word that hits you anywhere on the web!

    Quiz

    Are you a words master?

    »
    regarding something abstract as a material thing
    • A. mumblety-peg
    • B. hypostatization
    • C. swag
    • D. exponent

    Nearby & related entries:

    Alternative searches for tienilic acid: