What does thymidine kinase mean?
Definitions for thymidine kinase
thymi·dine kinase
This dictionary definitions page includes all the possible meanings, example usage and translations of the word thymidine kinase.
Wikidata
Thymidine kinase
Thymidine kinase is an enzyme, a phosphotransferase: 2'-deoxythymidine kinase, ATP-thymidine 5'-phosphotransferase, EC 2.7.1.21. It can be found in most living cells. It is present in two forms in mammalian cells, TK1 and TK2. Certain viruses also have genetic information for expression of viral thymidine kinases. Thymidine kinase catalyses the reaction: ⁕Thd + ATP → TMP + ADP where Thd is deoxythymidine, ATP is adenosine 5’-triphosphate, TMP is deoxythymidine 5’-phosphate and ADP is adenosine 5’-diphosphate. Thymidine kinases have a key function in the synthesis of DNA and thereby in cell division, as they are part of the unique reaction chain to introduce deoxythymidine into the DNA. Deoxythymidine is present in the body fluids as a result of degradation of DNA from food and from dead cells. Thymidine kinase is required for the action of many antiviral drugs. It is used to select hybridoma cell lines in production of monoclonal antibodies. In clinical chemistry it is used as a proliferation marker in the diagnosis, control of treatment and follow-up of malignant disease, mainly of hematological malignancies.
U.S. National Library of Medicine
Thymidine Kinase
An enzyme that catalyzes the conversion of ATP and thymidine to ADP and thymidine 5'-phosphate. Deoxyuridine can also act as an acceptor and dGTP as a donor. (From Enzyme Nomenclature, 1992) EC 2.7.1.21.
Numerology
Chaldean Numerology
The numerical value of thymidine kinase in Chaldean Numerology is: 2
Pythagorean Numerology
The numerical value of thymidine kinase in Pythagorean Numerology is: 4
Translations for thymidine kinase
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- 胸苷激Chinese
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"thymidine kinase." Definitions.net. STANDS4 LLC, 2024. Web. 26 Apr. 2024. <https://www.definitions.net/definition/thymidine+kinase>.
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