estrogen antagonist, tamoxifen(noun)
an antagonist for estrogen that is used in the treatment of breast cancer
A nonsteroidal estrogen antagonist used in the treatment of advanced breast cancer
Tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, and thus may be characterized as a mixed agonist/antagonist. Tamoxifen is the usual endocrine therapy for hormone receptor-positive breast cancer in pre-menopausal women, and is also a standard in post-menopausal women although aromatase inhibitors are also frequently used in that setting. Some breast cancer cells require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also bind to the estrogen receptor but do not activate it. Because of this competitive antagonism, tamoxifen acts like a key broken off in the lock that prevents any other key from being inserted, preventing estrogen from binding to its receptor. Hence breast cancer cell growth is blocked. Tamoxifen was discovered by pharmaceutical company Imperial Chemical Industries and is sold under the trade names Nolvadex, Istubal, and Valodex. However, the drug, even before its patent expiration, was and still is widely referred to by its generic name "tamoxifen."
U.S. National Library of Medicine
One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.
The numerical value of tamoxifen in Chaldean Numerology is: 4
The numerical value of tamoxifen in Pythagorean Numerology is: 8
Sample Sentences & Example Usage
I discussed it with my doctor, and … we both decided that I would go off of the Tamoxifen, and I’m feeling better all the time, i’m very lucky that so far, so good.
If a woman becomes post-menopausal during those five or 10 years she’s on tamoxifen, we will switch her to this other group of drugs that is 20 to 25 percent more effective.
The way tamoxifen works is you’re depriving your cancer cells of estrogen, which is their nutrition, so that will only work for the cancers that are estrogen-fed or progesterone-fed.
But that’s probably a combination of hormonal and lifestyle changes they’re going through. Tamoxifen can cause some fluid retention, and it could maybe cause a 2- or 3-pound weight gain, but beyond that there are probably other things going on as well.
Patients willsay I started taking tamoxifen and I gained 40 pounds, but that’s probably a combination of hormonal and lifestyle changes they’re going through. Tamoxifen can cause some fluid retention, and it could maybe cause a 2- or 3-pound weight gain, but beyond that there are probably other things going on as well.
Images & Illustrations of tamoxifen
Find a translation for the tamoxifen definition in other languages:
Select another language: