What does semustine mean?

Definitions for semustine
se·mus·tine

This dictionary definitions page includes all the possible meanings, example usage and translations of the word semustine.


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Wiktionary

  1. semustinenoun

    A drug used in chemotherapy, structurally similar to lomustine.

Wikipedia

  1. Semustine

    Semustine (1- (2-Chloroethyl)-3-(trans-4-methylcyclohexyl)- 1-nitrosourea, MeCCNU) is an alkylating nitrosourea compound used in chemotherapy treatment of various types of tumours. Due to its lipophilic property, semustine can cross the blood-brain barrier for the chemotherapy of brain tumours, where it interferes with the cellular DNA of the highly dividing cells. Semustine, just as lomustine, is administered orally. It has been reported that semustine can perform the main mechanism of action at molecular level via the alkylation of DNA nitrogenous bases in duplex by results of inhibition of DNA replication, transcription, and translation by way of alkylation of DNA, under pH-dependent conditions by hydrolysis, forming chloro-carbonium ions. Sufficient evidence was found that treatment with semustine can cause acute leukaemia as a delayed effect in very rare cases.

Wikidata

  1. Semustine

    Semustine is a drug used in chemotherapy. It is structurally similar to lomustine, being distinguished from it only by an additional methyl group. It has been taken off the drug market for investigation of its cancerous effects, rated as IARC Group 1 carcinogen or a known carcinogen.

U.S. National Library of Medicine

  1. Semustine

    4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.

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Numerology

  1. Chaldean Numerology

    The numerical value of semustine in Chaldean Numerology is: 9

  2. Pythagorean Numerology

    The numerical value of semustine in Pythagorean Numerology is: 8

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"semustine." Definitions.net. STANDS4 LLC, 2024. Web. 19 Mar. 2024. <https://www.definitions.net/definition/semustine>.

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