What does prothrombinase mean?
Definitions for prothrombinase
pro·throm·bi·nase
This dictionary definitions page includes all the possible meanings, example usage and translations of the word prothrombinase.
Princeton's WordNet
prothrombinase, factor Xnoun
coagulation factor that is converted to an enzyme that converts prothrombin to thrombin in a reaction that depends on calcium ions and other coagulation factors
Wikidata
Prothrombinase
The prothrombinase complex consists of the serine protease, Factor Xa, and the protein cofactor, Factor Va. The complex assembles on negatively charged phospholipid membranes in the presence of calcium ions. The prothrombinase complex catalyzes the conversion of prothrombin, an inactive zymogen, to thrombin, an active serine protease. The activation of thrombin is a critical reaction in the coagulation cascade, which functions to regulate hemostasis in the body. To produce thrombin, the prothrombinase complex cleaves two peptide bonds in prothrombin, one after Arg271 and the other after Arg320. Although it has been shown that Factor Xa can activate prothrombin when unassociated with the prothrombinase complex, the rate of thrombin formation is severely decreased under such circumstances. The prothrombinase complex can catalyze the activation of prothrombin at a rate 3 x 105-fold faster than can Factor Xa alone. Thus, the prothrombinase complex is required for the efficient production of activated thrombin and also for adequate hemostasis.
Matched Categories
Numerology
Chaldean Numerology
The numerical value of prothrombinase in Chaldean Numerology is: 2
Pythagorean Numerology
The numerical value of prothrombinase in Pythagorean Numerology is: 2
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"prothrombinase." Definitions.net. STANDS4 LLC, 2024. Web. 7 May 2024. <https://www.definitions.net/definition/prothrombinase>.
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