What does proenzyme mean?

Definitions for proenzyme
proʊˈɛn zaɪmproen·zyme

This dictionary definitions page includes all the possible meanings, example usage and translations of the word proenzyme.

Princeton's WordNet

  1. proenzyme, zymogennoun

    any of a group of compounds that are inactive precursors of enzymes and require some change (such as the hydrolysis of a fragment that masks an active enzyme) to become active

GCIDE

  1. proenzymenoun

    Any one of a class of proteins that are converted, in the normal course of cellular metabolism, into one or more active enzymes; also called zymogen. The conversion usually is due to a specific cleavage of a peptide bond by another enzyme, or may be due to acid.

Wiktionary

  1. proenzymenoun

    Any inactive precursor of an enzyme that is converted to an enzyme by proteolysis; a zymogen

Wikipedia

  1. proenzyme

    In biochemistry, a zymogen (), also called a proenzyme (), is an inactive precursor of an enzyme. A zymogen requires a biochemical change (such as a hydrolysis reaction revealing the active site, or changing the configuration to reveal the active site) for it to become an active enzyme. The biochemical change usually occurs in Golgi bodies, where a specific part of the precursor enzyme is cleaved in order to activate it. The inactivating piece which is cleaved off can be a peptide unit, or can be independently-folding domains comprising more than 100 residues. Although they limit the enzyme's ability, these N-terminal extensions of the enzyme or a “prosegment” often aid in the stabilization and folding of the enzyme they inhibit.The pancreas secretes zymogens partly to prevent the enzymes from digesting proteins in the cells in which they are synthesised. Enzymes like pepsin are created in the form of pepsinogen, an inactive zymogen. Pepsinogen is activated when chief cells release it into the gastric acid, whose hydrochloric acid partially activates it. Another partially inactivated pepsinogen completes the activation by removing the peptide, turning the pepsinogen into pepsin. Accidental activation of zymogens can happen when the secretion duct in the pancreas is blocked by a gallstone, resulting in acute pancreatitis.Fungi also secrete digestive enzymes into the environment as zymogens. The external environment has a different pH than inside the fungal cell and this changes the zymogen's structure into an active enzyme.Another way that enzymes can exist in inactive forms and later be converted to active forms is by activating only when a cofactor, called a coenzyme, is bound. In this system, the inactive form (the apoenzyme) becomes the active form (the holoenzyme) when the coenzyme binds. In the duodenum, the pancreatic zymogens, trypsinogen, chymotrypsinogen, proelastase and procarboxypeptidase are converted into active enzymes by enteropeptidase and trypsin. Chymotrypsinogen, is single polypeptide chain of 245 amino acids residues, is converted to alpha-chymotrypsin, which has three polypeptide chains linked by two of the five disulfide bond present in the primary structure of chymotrypsinogen.

ChatGPT

  1. proenzyme

    A proenzyme, also known as a zymogen, is an inactive precursor of an enzyme. It requires some form of activation, often through the cleavage of a polypeptide segment, to become a fully active enzyme. This process of conversion allows for the regulation of enzyme activity inside cells or in biological processes.

Editors Contribution

  1. proenzyme

    A type of protein.

    Proenzyme is another word for zymogen which are various enzyme precursor molecules that may change into an enzyme as a result of catalytic change.


    Submitted by MaryC on October 6, 2015  

Matched Categories

How to pronounce proenzyme?

How to say proenzyme in sign language?

Numerology

  1. Chaldean Numerology

    The numerical value of proenzyme in Chaldean Numerology is: 8

  2. Pythagorean Numerology

    The numerical value of proenzyme in Pythagorean Numerology is: 2

Translation

Find a translation for the proenzyme definition in other languages:

Select another language:

  • - Select -
  • 简体中文 (Chinese - Simplified)
  • 繁體中文 (Chinese - Traditional)
  • Español (Spanish)
  • Esperanto (Esperanto)
  • 日本語 (Japanese)
  • Português (Portuguese)
  • Deutsch (German)
  • العربية (Arabic)
  • Français (French)
  • Русский (Russian)
  • ಕನ್ನಡ (Kannada)
  • 한국어 (Korean)
  • עברית (Hebrew)
  • Gaeilge (Irish)
  • Українська (Ukrainian)
  • اردو (Urdu)
  • Magyar (Hungarian)
  • मानक हिन्दी (Hindi)
  • Indonesia (Indonesian)
  • Italiano (Italian)
  • தமிழ் (Tamil)
  • Türkçe (Turkish)
  • తెలుగు (Telugu)
  • ภาษาไทย (Thai)
  • Tiếng Việt (Vietnamese)
  • Čeština (Czech)
  • Polski (Polish)
  • Bahasa Indonesia (Indonesian)
  • Românește (Romanian)
  • Nederlands (Dutch)
  • Ελληνικά (Greek)
  • Latinum (Latin)
  • Svenska (Swedish)
  • Dansk (Danish)
  • Suomi (Finnish)
  • فارسی (Persian)
  • ייִדיש (Yiddish)
  • հայերեն (Armenian)
  • Norsk (Norwegian)
  • English (English)

Word of the Day

Would you like us to send you a FREE new word definition delivered to your inbox daily?

Please enter your email address:


Citation

Use the citation below to add this definition to your bibliography:

Style:MLAChicagoAPA

"proenzyme." Definitions.net. STANDS4 LLC, 2024. Web. 21 May 2024. <https://www.definitions.net/definition/proenzyme>.

Discuss these proenzyme definitions with the community:

0 Comments

    Are we missing a good definition for proenzyme? Don't keep it to yourself...

    Free, no signup required:

    Add to Chrome

    Get instant definitions for any word that hits you anywhere on the web!

    Free, no signup required:

    Add to Firefox

    Get instant definitions for any word that hits you anywhere on the web!

    Browse Definitions.net

    Quiz

    Are you a words master?

    »
    be hungry; go without food
    A emanate
    B transpire
    C abhor
    D famish

    Nearby & related entries:

    Alternative searches for proenzyme: