Definitions for pertuzumab
per·tuzum·ab

WiktionaryRate this definition:0.0 / 0 votes

1. pertuzumabnoun

   A monoclonal antibody being developed as a drug to slow tumour growth.

WikipediaRate this definition:0.0 / 0 votes

1. Pertuzumab

   Pertuzumab, sold under the brand name Perjeta, is a monoclonal antibody used in combination with trastuzumab and docetaxel for the treatment of metastatic HER2-positive breast cancer; it also used in the same combination as a neoadjuvant in early HER2-positive breast cancer.Side effects in more than half the people taking it include diarrhea, hair loss, and loss of neutrophils; more than 10% experience loss of red blood cells, hypersensitivity or allergic reaction, infusion reactions, decreased appetite, insomnia, distortions in the sense of taste, inflammation of the mouth or lips, constipation, rashes, nail disease, and muscle pain. Women who are pregnant or planning on getting pregnant should not take it, it was not studied in people with certain heart conditions and should be used in caution in such people, and it should not be used with an anthracycline. It is unknown if pertuzumab interacts with doxorubicin.It is the first-in-class of a kind of drug called a "HER dimerization inhibitor" — it inhibits the dimerization of HER2 with other HER receptors, which prevents them from signalling in ways that promote cell growth and proliferation.It was discovered and developed by Genentech and was first approved in 2012.

WikidataRate this definition:0.0 / 0 votes

1. Pertuzumab

   Pertuzumab is a monoclonal antibody. The first of its class in a line of agents called "HER dimerization inhibitors". By binding to HER2, it inhibits the dimerization of HER2 with other HER receptors, which is hypothesized to result in slowed tumor growth. Pertuzumab received US FDA approval for the treatment of HER2-positive metastatic breast cancer on June 8, 2012. Pertuzumab was developed at Genentech and is now owned by Roche which acquired Genentech in 2009.

How to pronounce pertuzumab?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say pertuzumab in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of pertuzumab in Chaldean Numerology is: 9

2. Pythagorean Numerology

   The numerical value of pertuzumab in Pythagorean Numerology is: 8

Examples of pertuzumab in a Sentence

1. Andrew Dillon:

   In order to be able to recommend pertuzumab as an addition to trastuzumab and chemotherapy, the committee needed to have more evidence of its long-term clinical benefits, particularly its impact on overall survival.

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Pertuzumab
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Pertuzumab
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=pertuzumab