What does peripheral tolerance mean?
Definitions for peripheral tolerance
pe·riph·er·al tol·er·ance
This dictionary definitions page includes all the possible meanings, example usage and translations of the word peripheral tolerance.
Wikipedia
Peripheral tolerance
Peripheral tolerance is the second branch of immunological tolerance, after central tolerance. It takes place in the immune periphery (after T and B cells egress from primary lymphoid organs). Its main purpose is to ensure that self-reactive T and B cells which escaped central tolerance do not cause autoimmune disease.Mechanisms of peripheral tolerance include direct inactivation of effector T cells by either clonal deletion, conversion to regulatory T cells (Tregs) or induction of anergy. Tregs, which are also generated during thymic T cell development, further suppress the effector functions of conventional lymphocytes in the periphery. Dependence of a particular antigen on either central or peripheral tolerance is determined by its abundance in the organism. B cell peripheral tolerance is much less studied and is largely mediated by B cell dependence on T cell help.
Numerology
Chaldean Numerology
The numerical value of peripheral tolerance in Chaldean Numerology is: 3
Pythagorean Numerology
The numerical value of peripheral tolerance in Pythagorean Numerology is: 3
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"peripheral tolerance." Definitions.net. STANDS4 LLC, 2024. Web. 10 May 2024. <https://www.definitions.net/definition/peripheral+tolerance>.
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