What does oxidopamine mean?
Definitions for oxidopamine
ox·i·dopamine
This dictionary definitions page includes all the possible meanings, example usage and translations of the word oxidopamine.
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Wikipedia
Oxidopamine
Oxidopamine, also known as 6-hydroxydopamine (6-OHDA) or 2,4,5-trihydroxyphenethylamine, is a neurotoxic synthetic organic compound used by researchers to selectively destroy dopaminergic and noradrenergic neurons in the brain. The main use for oxidopamine in scientific research is to induce Parkinsonism in laboratory animals by lesioning the dopaminergic neurons of the substantia nigra pars compacta, in order to develop and test new medicines and treatments for Parkinson's disease.
Wikidata
Oxidopamine
Oxidopamine, also known as 6-hydroxydopamine or 2,4,5-trihydroxyphenethylamine, is a neurotoxic synthetic organic compound used by researchers to selectively destroy dopaminergic and noradrenergic neurons in the brain. 6-OHDA is thought to enter the neurons via the dopamine and noradrenaline reuptake transporters. Oxidopamine is often used in conjunction with a selective noradrenaline reuptake inhibitor to selectively destroy dopaminergic neurons only. The main use for oxidopamine in scientific research is to induce Parkinsonism in laboratory animals such as mice, rats and monkeys, in order to develop and test new medicines and treatments for Parkinson's disease. In order to induce this condition in animals, around 70% of the dopaminergic neurons in the substantia nigra of the brain must be destroyed, and this is achieved either with oxidopamine or MPTP. Both these agents likely destroy neurons by generating reactive oxygen species such as superoxide radical. Oxidopamine toxicity in neonatal rodents is also used as an animal model for the Lesch-Nyhan syndrome.
U.S. National Library of Medicine
Oxidopamine
A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
Numerology
Chaldean Numerology
The numerical value of oxidopamine in Chaldean Numerology is: 3
Pythagorean Numerology
The numerical value of oxidopamine in Pythagorean Numerology is: 8
Translations for oxidopamine
From our Multilingual Translation Dictionary
- oksydopaminaPolish
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"oxidopamine." Definitions.net. STANDS4 LLC, 2024. Web. 26 Apr. 2024. <https://www.definitions.net/definition/oxidopamine>.
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