What does oligoclonal band mean?
Definitions for oligoclonal band
oligo·clonal band
This dictionary definitions page includes all the possible meanings, example usage and translations of the word oligoclonal band.
Wiktionary
oligoclonal bandnoun
One of bands of immunoglobulins that are seen when a patient's blood plasma or cerebrospinal fluid (CSF) is analyzed.
Wikipedia
Oligoclonal band
Oligoclonal bands (OCBs) are bands of immunoglobulins that are seen when a patient's blood serum, or cerebrospinal fluid (CSF) is analyzed. They are used in the diagnosis of various neurological and blood diseases, especially in multiple sclerosis. Two methods of analysis are possible: (a) protein electrophoresis, a method of analyzing the composition of fluids, also known as "SDS-PAGE (sodium dodecyl sulphate polyacrylamide gel electrophoresis)/Coomassie blue staining", and (b) the combination of isoelectric focusing/silver staining. The latter is more sensitive.For the analysis of cerebrospinal fluid, a sample is first collected via lumbar puncture (LP). Normally it is assumed that all the proteins that appear in the CSF, but are not present in the serum, are produced intrathecally (inside the central nervous system). Therefore, it is normal to subtract bands in serum from bands in CSF when investigating CNS diseases. A sample of blood serum is usually obtained from a clotted blood sample taken around the time of the LP.
Wikidata
Oligoclonal band
Oligoclonal bands are bands of immunoglobulins that are seen when a patient's blood serum, gained from blood plasma, or cerebrospinal fluid is analyzed. Two methods of analysis are possible: protein electrophoresis, a method of analyzing the composition of fluids, also known as "agarose gel electrophoresis/Coomassie Blue staining", and the combination of isoelectric focusing/silver staining. The latter is more sensitive. For the analysis of cerebrospinal fluid, a patient has a lumbar puncture performed, which collects some of his or her cerebrospinal fluid. Each of the two to five oligoclonal bands seen by protein electrophoresis represent proteins secreted by plasma cells, although why exactly these bands are present, and which proteins these bands represent, has not yet been elucidated.
Numerology
Chaldean Numerology
The numerical value of oligoclonal band in Chaldean Numerology is: 1
Pythagorean Numerology
The numerical value of oligoclonal band in Pythagorean Numerology is: 1
Translations for oligoclonal band
From our Multilingual Translation Dictionary
- banda oligoclonalSpanish
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"oligoclonal band." Definitions.net. STANDS4 LLC, 2024. Web. 12 May 2024. <https://www.definitions.net/definition/oligoclonal+band>.
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