Definitions for neuroleptic malignant syndrome
neu·rolep·tic ma·lig·nan·t syn·drome

WiktionaryRate this definition:0.0 / 0 votes

1. neuroleptic malignant syndromenoun

   A life-threatening neurological disorder, exhibiting muscle rigidity, fever, delirium, etc., most often caused by an adverse reaction to neuroleptic or antipsychotic drugs.

WikipediaRate this definition:0.0 / 0 votes

1. Neuroleptic malignant syndrome

   Neuroleptic malignant syndrome (NMS) is a rare but life-threatening reaction that can occur in response to neuroleptic or antipsychotic medication. Symptoms include high fever, confusion, rigid muscles, variable blood pressure, sweating, and fast heart rate. Complications may include rhabdomyolysis, high blood potassium, kidney failure, or seizures.Any medications within the family of neuroleptics can cause the condition, though typical antipsychotics appear to have a higher risk than atypicals, specifically first generation antipsychotics like haloperidol. Onset is often within a few weeks of starting the medication but can occur at any time. Risk factors include dehydration, agitation, and catatonia.Rapidly decreasing the use of levodopa or other dopamine agonists, such as pramipexole, may also trigger the condition. The underlying mechanism involves blockage of dopamine receptors. Diagnosis is based on symptoms.Management includes stopping the triggering medication, rapid cooling, and starting other medications. Medications used include dantrolene, bromocriptine, and diazepam. The risk of death among those affected is about 10%. Rapid diagnosis and treatment is required to improve outcomes. Many people can eventually be restarted on a lower dose of antipsychotic.As of 2011, among those in psychiatric hospitals on neuroleptics about 15 per 100,000 are affected per year (0.015%). In the second half of the 20th century rates were over 100 times higher at about 2% (2,000 per 100,000). Males appear to be more often affected than females. The condition was first described in 1956.

WikidataRate this definition:0.0 / 0 votes

1. Neuroleptic malignant syndrome

   Neuroleptic malignant syndrome is a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic drugs. NMS typically consists of muscle rigidity, fever, autonomic instability, and cognitive changes such as delirium, and is associated with elevated plasma creatine phosphokinase. The incidence of neuroleptic malignant syndrome has decreased since it was first described, due to changes in prescribing habits, but NMS is still a potential danger to patients being treated with antipsychotic medication. Because of the unpredictability of NMS, treatment may vary substantially but is generally based on supportive care and removal of the offending antipsychotic drug.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Neuroleptic Malignant Syndrome

   A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)

How to pronounce neuroleptic malignant syndrome?

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Numerology

1. Chaldean Numerology

   The numerical value of neuroleptic malignant syndrome in Chaldean Numerology is: 8

2. Pythagorean Numerology

   The numerical value of neuroleptic malignant syndrome in Pythagorean Numerology is: 9

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Neuroleptic_Malignant_Syndrome
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Neuroleptic_Malignant_Syndrome
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=neuroleptic malignant syndrome