Definitions for lamotrigine
lam·ot·rig·ine

WiktionaryRate this definition:0.0 / 0 votes

1. lamotriginenoun

   An anticonvulsant drug used in the treatment of epilepsy

WikipediaRate this definition:0.0 / 0 votes

1. Lamotrigine

   Lamotrigine, sold under the brand name Lamictal among others, is a medication used to treat epilepsy and stabilize mood in bipolar disorder. For epilepsy, this includes focal seizures, tonic-clonic seizures, and seizures in Lennox-Gastaut syndrome. In bipolar disorder, lamotrigine has not been shown to reliably treat acute depression; but for patients with bipolar disorder who are not currently symptomatic, it appears to be effective in reducing the risk of future episodes of depression.Common side effects include nausea, sleepiness, headache, vomiting, trouble with coordination, and rash. Serious side effects include lack of red blood cells, increased risk of suicide, Stevens–Johnson syndrome, and allergic reactions, which can be fatal. Concerns exist that use during pregnancy or breastfeeding may result in harm. Lamotrigine is a phenyltriazine, making it chemically different from other anticonvulsants. Its mechanism of action is not clear, but it appears to inhibit release of excitatory neurotransmitters via voltage-sensitive sodium channels and voltage-gated calcium channels in neurons. Lamotrigine was first marketed in Ireland in 1991, and approved for use in the United States in 1994. It is on the World Health Organization's List of Essential Medicines. In 2020, it was the 62nd most commonly prescribed medication in the United States, with more than 10 million prescriptions.

WikidataRate this definition:0.0 / 0 votes

1. Lamotrigine

   Lamotrigine, marketed in the US and most of Europe as Lamictal by GlaxoSmithKline, is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. It is also used off-label as an adjunct in treating depression. For epilepsy, it is used to treat focal seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Like many other anticonvulsant medications, Lamotrigine also seems to act as an effective mood stabilizer, and has been the first U.S. Food and Drug Administration-approved drug for this purpose since lithium, a drug approved almost 30 years earlier. It is approved for the maintenance treatment of bipolar type I. Chemically unrelated to other anticonvulsants, lamotrigine has many possible side-effects. Lamotrigine is generally accepted to be a member of the sodium channel blocking class of antiepileptic drugs, but it could have additional actions since it has a broader spectrum of action than other sodium channel antiepileptic drugs such as phenytoin and carbamazepine and is effective in the treatment of the depressed phase of bipolar disorder, whereas other sodium channel blocking antiepileptic drugs are not. In addition, lamotrigine shares few side-effects with other, unrelated anticonvulsants known to inhibit sodium channels, which further emphasizes its unique properties. Lamotrigine is inactivated by hepatic glucuronidation.

How to pronounce lamotrigine?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say lamotrigine in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of lamotrigine in Chaldean Numerology is: 9

2. Pythagorean Numerology

   The numerical value of lamotrigine in Pythagorean Numerology is: 6

Examples of lamotrigine in a Sentence

1. Cameron Heron:

   Carmen Heron, who is speaking out on behalf of her daughter, who is now legally deaf because of SJS, said.I get emotional even thinking about it. Im just so excited for her. She is still dealing with the aftermath of SJS now, and I do worry and think, Is this the life shes going to have ? But now, its not shell have a new life as a mum. For Heron, who was an apprentice chef at a top Sydney restaurant when she became ill, but can no longer work, life changed forever in early 2014, when she was diagnosed with epilepsy. Right away, she was placed on two drugs commonly prescribed to help manage seizures levetiracetam, more commonly known as Keppra, and lamotrigine, sold under the brand name Lamictal. It took three weeks in the hospital before her condition started improving, although she still deals with lasting hearing loss and PTSD from the ordeal. ( PA Real Life) While serious side effects are extremely rare, both drugs carry the risk of triggering a severe cutaneous adverse reaction - such as SJS according to The National Institute for Health and Care Excellence( NICE). At first, Heron appeared to be responding well to medication, until a pinprick-like rash appeared in May. I knew right away that it was an allergic reaction, and so I took her to the doctor and asked them to change the medication she was on.

Popularity rank by frequency of use

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Lamotrigine
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Lamotrigine
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=lamotrigine