Definitions for ketoconazole
ke·to·cona·zole

WiktionaryRate this definition:0.0 / 0 votes

1. ketoconazolenoun

   A synthetic antifungal drug used especially in immunocompromised patients.

WikipediaRate this definition:0.0 / 0 votes

1. Ketoconazole

   Ketoconazole, sold under the brand name Nizoral among others, is an antiandrogen and antifungal medication used to treat a number of fungal infections. Applied to the skin it is used for fungal skin infections such as tinea, cutaneous candidiasis, pityriasis versicolor, dandruff, and seborrheic dermatitis. Taken by mouth it is a less preferred option and only recommended for severe infections when other agents cannot be used. Other uses include treatment of excessive male-patterned hair growth in women and Cushing's syndrome.Common side effects when applied to the skin include redness. Common side effects when taken by mouth include nausea, headache, and liver problems. Liver problems may result in death or the need for a liver transplantation. Other severe side effects when taken by mouth include QT prolongation, adrenocortical insufficiency, and anaphylaxis. It is an imidazole and works by hindering the production of ergosterol required for the fungal cell membrane, thereby slowing growth.Ketoconazole was patented in 1977 by Belgian pharmaceutical company Janssen, and came into medical use in 1981. It is available as a generic medication and formulations that are applied to the skin are over the counter in the United Kingdom. In 2020, it was the 170th most commonly prescribed medication in the United States, with more than 3 million prescriptions. The formulation that is taken by mouth was withdrawn in the European Union and in Australia in 2013, and in China in 2015. In addition, its use was restricted in the United States and Canada in 2013.

WikidataRate this definition:0.0 / 0 votes

1. Ketoconazole

   Ketoconazole is a synthetic, imidazole-derived antifungal medication used primarily to treat fungal infections. Ketoconazole is sold commercially as a tablet for oral administration, and in a variety of formulations, such as creams and shampoos, for topical administration. Ketoconazole is very lipophilic and tends to accumulate in fatty tissues. The less toxic and generally more effective triazole compounds fluconazole and itraconazole are usually preferred for internal use. Ketoconazole is best absorbed at highly acidic levels, so antacids or other causes of decreased stomach acid levels will lower the drug's absorption when taken orally. Absorption can be increased by taking it with an acidic beverage, such as cola.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Ketoconazole

   Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.

How to pronounce ketoconazole?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say ketoconazole in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of ketoconazole in Chaldean Numerology is: 2

2. Pythagorean Numerology

   The numerical value of ketoconazole in Pythagorean Numerology is: 7

Popularity rank by frequency of use

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Ketoconazole
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Ketoconazole
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=ketoconazole