Definitions for keratohyalin
ker·a·to·hyalin

Princeton's WordNetRate this definition:0.0 / 0 votes

1. keratohyalinnoun

   hyaline in the large granules of the stratum granulosum

WiktionaryRate this definition:0.0 / 0 votes

1. keratohyalinnoun

   A protein structure found in granules in the stratum granulosum of the epidermis, which may be involved in keratinization, and in Hassall corpuscles in the thymus.

WikipediaRate this definition:0.0 / 0 votes

1. Keratohyalin

   Keratohyalin is a protein structure found in cytoplasmic granules of the keratinocytes in the stratum granulosum of the epidermis. Keratohyalin granules (KHG) mainly consist of keratin, profilaggrin, loricrin and trichohyalin proteins which contribute to cornification or keratinization, the process of the formation of epidermal cornified cell envelope. During the keratinocyte differentiation, these granules maturate and expand in size, which leads to the conversion of keratin tonofilaments into a homogenous keratin matrix, an important step in cornification.Keratohyalin granules can be divided in three classes: globular KHG (found in quickly dividing epithelia, such as the oral mucose), stellate KHG (found in the slowly dividing normal epidermis) and KHG of Hassall's corpuscles or type VI epithelioreticular cells of the thymus gland. The exact purpose of the keratinization of Hassall's corpuscles remains unknown. During skin differentiation process, keratohyaline granules discharge their contents in the junction between stratum granulosum and stratum corneum cell layers and form the barrier. At the same time, the inner side of the cell membrane thickens forming the cornified cell envelope. After the release of the granules, nuclei, ribosomes and mitochondria disappear, the cells become densely packaged with filaggrin and cover more surface. After final dehydration, the cell desquamates.The release of keratohyalin granules plays an important role in the skin moisturization. Filaggrin undergoes chemical modification and proteolytic processing which leads to the formation of natural moisturizing factor (NMF), hygroscopic amino acids and derivatives which function as UV protectant, modulate stratum corneum pH and water retention.

ChatGPTRate this definition:0.0 / 0 votes

1. keratohyalin

   Keratohyalin is a granular substance found in the epidermis layers of the skin. It plays a crucial role in the process of keratinization, where it helps in the formation and regulation of the protein keratin, which is vital for maintaining a healthy skin barrier.

WikidataRate this definition:0.0 / 0 votes

1. Keratohyalin

   Keratohyalin is a protein structure found in granules in the stratum granulosum of the epidermis, which may be involved in keratinization, and in Hassall corpuscles in the thymus. In H&E stained sections, they are large deeply stained granules found in the cytoplasm of epithelial cells in keratinized oral mucosa. Keratohyalin is associated with eleidin, the intermediate between keratohyalin and keratin; histological location is in the stratum lucidum, thick skin. In the stratum granulosum, the "grainy" third layer of the human epidermis, the protein Keratohyalin forms dense cytoplasmic granules that promote dehydration of the cell as well as aggregation and cross-linking of the keratin fibers. The nuclei and other organelles then disintegrate, and the cells die. Further dehydration creates a tightly interlocked layer of cells that consists of keratin fibers surrounded by keratohyalin.

Matched Categories

1. • Hyaline

How to pronounce keratohyalin?

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Numerology

1. Chaldean Numerology

   The numerical value of keratohyalin in Chaldean Numerology is: 1

2. Pythagorean Numerology

   The numerical value of keratohyalin in Pythagorean Numerology is: 4

References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=keratohyalin
2. ^ Wiktionary
   https://en.wiktionary.org/wiki/Keratohyalin
3. ^ Wikipedia
   https://en.wikipedia.org/wiki/Keratohyalin
4. ^ ChatGPT
   https://chat.openai.com
5. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=keratohyalin