Definitions for hypereosinophilia
hy·per·e·osinophil·i·a

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1. hypereosinophilia

   Eosinophilia is a condition in which the eosinophil count in the peripheral blood exceeds 5×108/L (500/μL). Hypereosinophilia is an elevation in an individual's circulating blood eosinophil count above 1.5 × 109/L (i.e. 1,500/μL). The hypereosinophilic syndrome is a sustained elevation in this count above 1.5 × 109/L (i.e. 1,500/μL) that is also associated with evidence of eosinophil-based tissue injury. Eosinophils usually account for less than 7% of the circulating leukocytes. A marked increase in non-blood tissue eosinophil count noticed upon histopathologic examination is diagnostic for tissue eosinophilia. Several causes are known, with the most common being some form of allergic reaction or parasitic infection. Diagnosis of eosinophilia is via a complete blood count (CBC), but diagnostic procedures directed at the underlying cause vary depending on the suspected condition(s). An absolute eosinophil count is not generally needed if the CBC shows marked eosinophilia. The location of the causal factor can be used to classify eosinophilia into two general types: extrinsic, in which the factor lies outside the eosinophil cell lineage; and intrinsic eosinophilia, which denotes etiologies within the eosiniphil cell line. Specific treatments are dictated by the causative condition, though in idiopathic eosinophilia, the disease may be controlled with corticosteroids. Eosinophilia is not a disorder (rather, only a sign) unless it is idiopathic.Informally, blood eosinophil levels are often regarded as mildly elevated at counts of 500–1,500/μL, moderately elevated between 1,500 and 5,000/μL, and severely elevated when greater than 5,000/μL. Elevations in blood eosinophil counts can be transient, sustained, recurrent, or cyclical.Eosinophil counts in human blood normally range between 100 and 500 per/μL. Maintenance of these levels results from a balance between production of eosinophils by bone marrow eosinophil precursor cells termed CFU-Eos and the emigration of circulating eosinophils out of the blood through post-capillary venules into tissues. Eosinophils represent a small percentage of peripheral blood leucocytes (usually less than 8%), have a half-life in the circulation of only 8–18 hours, but persist in tissues for at least several weeks.Eosinophils are one form of terminally differentiated granulocytes; they function to neutralize invading microbes, primarily parasites and helminthes but also certain types of fungi and viruses. They also participate in transplant rejection, Graft-versus-host disease, and the killing of tumor cells. In conducting these functions, eosinophils produce and release on demand a range of toxic reactive oxygen species (e.g. hypobromite, hypobromous acid, superoxide, and peroxide) and they also release on demand a preformed armamentarium of cytokines, chemokines, growth factors, lipid mediators (e.g. leukotrienes, prostaglandins, platelet activating factor), and toxic proteins (e.g. metalloproteinases, major basic protein, eosinophil cationic protein, eosinophil peroxidase, and eosinophil-derived neurotoxin). These agents serve to orchestrate robust immune and inflammatory responses that destroy invading microbes, foreign tissue, and malignant cells. When overproduced and over-activated, which occurs in certain cases of hypereosinophilia and to a lesser extent eosinophilia, eosinophils may misdirect their reactive oxygen species and armamentarium of preformed molecules toward normal tissues. This can result in serious damage to such organs as the lung, heart, kidneys, and brain.

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1. Hypereosinophilia

   Hypereosinophilia is a disease characterised by a marked increase in the eosinophil count in the bloodstream. The eosinophil count in human blood is normally 0.4 × 109/L and results from a balance between production of eosinophils and emigration through post-capillary venules. Eosinophils are only a small minority of peripheral blood leucocytes and in normal subjects, most are found in the tissues of the lung and gastro-intestinal tract. Blood eosinophil counts are arbitrarily classified as mild - between 0.6 to 1.5 × 109/L; moderate between 1.5 to 5 × 109/L and severe when greater than 5 × 109/L. An elevated blood eosinophil count may be associated with a number of reactive conditions and with clonal disorders of the bone marrow. However, when the blood eosinophil count is persistently greater than 1.5 × 109 /L, for a period of more than six months, damage to end organs such as the heart, lungs, skin, joints and nervous system can be demonstrated, and in the absence of any clonal or reactive cause, the term idiopathic hypereosinophilic syndrome is used. The three defining criteria of HES are therefore: ⁕Eosinophil count persistently greater than 1.5 × 109/L

How to pronounce hypereosinophilia?

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Numerology

1. Chaldean Numerology

   The numerical value of hypereosinophilia in Chaldean Numerology is: 5

2. Pythagorean Numerology

   The numerical value of hypereosinophilia in Pythagorean Numerology is: 6

References

1. ^ Wikipedia
   https://en.wikipedia.org/wiki/Hypereosinophilia
2. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=hypereosinophilia