What does homotaurine mean?
Definitions for homotaurine
ho·mo·tau·rine
This dictionary definitions page includes all the possible meanings, example usage and translations of the word homotaurine.
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Wiktionary
homotaurinenoun
A synthetic organic compound, analogous to taurine but with an extra carbon in its chain, potentially useful as an anticonvulsant and treatment for Alzheimer's disease.
Wikipedia
Homotaurine
Homotaurine (also known as tramiprosate (INN), 3-amino-1-propanesulfonic acid, or 3-APS) is a natural sulfonic acid found in seaweed. It is analogous to taurine, but with an extra carbon in its chain. It has GABAergic activity, apparently by mimicking GABA, which it resembles.Homotaurine was investigated in a Phase III clinical trial as a potential treatment for Alzheimer's disease (AD) that did not show efficacy. However, post-hoc analyses have shown positive and significant effects of homotaurine on secondary endpoints and subgroups of patients, including a reduction in hippocampal volume loss and lower decline in memory function in the overall cohort, as well as a reduction in global cognitive decline in APOE4 allele carriers, suggesting a disease-modifying effect. A study in cognitive impairment done in 2018 did show positive benefits.Homotaurine is currently in a phase 3 study with expected FDA approval as the first disease modifying drug for AD.
Wikidata
Homotaurine
Homotaurine is a synthetic organic compound. It is analogous to taurine, but with an extra carbon in its chain. Because of its similarity in structure to the neurotransmitter gamma-aminobutyric acid, it has GABAergic effects and may be useful as an anticonvulsant. Homotaurine has also been investigated as a potential treatment for Alzheimer's disease. It binds to soluble amyloid beta and inhibits the formation of neurotoxic aggregates that lead to amyloid plaque deposition in the brain. However, clinical trials failed to show value. Homotaurine is a zwitterion at neutral pH.
Numerology
Chaldean Numerology
The numerical value of homotaurine in Chaldean Numerology is: 2
Pythagorean Numerology
The numerical value of homotaurine in Pythagorean Numerology is: 4
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"homotaurine." Definitions.net. STANDS4 LLC, 2024. Web. 27 Apr. 2024. <https://www.definitions.net/definition/homotaurine>.
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