What does hmg-coa reductase mean?
Definitions for hmg-coa reductase
hmg-coa reductase
This dictionary definitions page includes all the possible meanings, example usage and translations of the word hmg-coa reductase.
Princeton's WordNet
HMG-CoA reductase, 5-hydroxy-3-methylglutaryl-coenzyme A reductasenoun
a liver enzyme that is responsible for producing cholesterol
ChatGPT
hmg-coa reductase
HMG-CoA reductase, or 3-hydroxy-3-methylglutaryl-CoA reductase, is an enzyme that plays a key role in the mevalonate pathway, where it catalyzes the conversion of HMG-CoA to mevalonate. This is a crucial step in the production of cholesterol and other sterols in the body. Because of its role in cholesterol synthesis, inhibitors of this enzyme (such as statin drugs) are commonly used to treat high cholesterol.
Wikidata
HMG-CoA reductase
HMG-CoA reductase is the rate-controlling enzyme of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein via the LDL receptor as well as oxidized species of cholesterol. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. This enzyme is thus the target of the widely available cholesterol-lowering drugs known collectively as the statins. HMG-CoA reductase is anchored in the membrane of the endoplasmic reticulum, and was long regarded as having seven transmembrane domains, with the active site located in a long carboxyl terminal domain in the cytosol. More recent evidence shows it to contain eight transmembrane domains. The enzyme commission designation is EC 1.1.1.34 for the NADPH-dependent enzyme, whereas 1.1.1.88 links to an NADH-dependent enzyme.
Matched Categories
Numerology
Chaldean Numerology
The numerical value of hmg-coa reductase in Chaldean Numerology is: 2
Pythagorean Numerology
The numerical value of hmg-coa reductase in Pythagorean Numerology is: 8
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"hmg-coa reductase." Definitions.net. STANDS4 LLC, 2024. Web. 26 Apr. 2024. <https://www.definitions.net/definition/hmg-coa+reductase>.
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