Definitions for histidine decarboxylase
his·ti·dine de·car·boxy·lase

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1. Histidine decarboxylase

   The enzyme histidine decarboxylase (EC 4.1.1.22, HDC) is transcribed on chromosome 15, region q21.1-21.2, and catalyzes the decarboxylation of histidine to form histamine. In mammals, histamine is an important biogenic amine with regulatory roles in neurotransmission, gastric acid secretion and immune response. Histidine decarboxylase is the sole member of the histamine synthesis pathway, producing histamine in a one-step reaction. Histamine cannot be generated by any other known enzyme. HDC is therefore the primary source of histamine in most mammals and eukaryotes. The enzyme employs a pyridoxal 5'-phosphate (PLP) cofactor, in similarity to many amino acid decarboxylases. Eukaryotes, as well as gram-negative bacteria share a common HDC, while gram-positive bacteria employ an evolutionarily unrelated pyruvoyl-dependent HDC. In humans, histidine decarboxylase is encoded by the HDC gene.

WikidataRate this definition:0.0 / 0 votes

1. Histidine decarboxylase

   Histidine decarboxylase is the enzyme that catalyzes the reaction that produces histamine from histidine with the help of vitamin B6 as follows: Known inhibitors of histidine decarboxylase : catechin, tritoqualine an atypical antihistaminic. C6H9N3O2 → C5H9N3 + CO2 In humans, the histidine decarboxylase enzyme is encoded by the HDC gene. The biogenic amine histamine is an important modulator of numerous physiologic processes, including neurotransmission, gastric acid secretion, and smooth muscle tone. The biosynthesis of histamine from histidine is catalyzed by the enzyme L-histidine decarboxylase. This homodimeric enzyme is a pyridoxal phosphate-dependent decarboxylase and is highly specific for its histidine substrate. Some mutations in the gene for this enzyme can cause symptoms of Tourette syndrome; however, these mutations have only been observed in one family and are not thought to account for most cases of Tourette syndrome. In bacteria, it is synthesised as a proenzyme, PI. Cleavage of the proenzyme PI chain yields two subunits, alpha and beta, which arrange as a hexamer, 6, by nonhydrolytic self-catalysis.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Histidine Decarboxylase

   An enzyme that catalyzes the decarboxylation of histidine to histamine and carbon dioxide. It requires pyridoxal phosphate in animal tissues, but not in microorganisms. EC 4.1.1.22.

How to pronounce histidine decarboxylase?

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Numerology

1. Chaldean Numerology

   The numerical value of histidine decarboxylase in Chaldean Numerology is: 8

2. Pythagorean Numerology

   The numerical value of histidine decarboxylase in Pythagorean Numerology is: 6

References

1. ^ Wikipedia
   https://en.wikipedia.org/wiki/Histidine_Decarboxylase
2. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=histidine decarboxylase