Definitions for guggulsterone
gug·gul·s·terone

WiktionaryRate this definition:0.0 / 0 votes

1. guggulsteronenoun

   A steroid, present in the resin of the guggul plant, Commiphora mukul, that is used in some medical preparations

WikipediaRate this definition:0.0 / 0 votes

1. Guggulsterone

   Guggulsterone is a phytosteroid found in the resin of the guggul plant, Commiphora mukul. Guggulsterone can exist as either of two stereoisomers, E-guggulsterone and Z-guggulsterone. In humans, it acts as an antagonist of the farnesoid X receptor, which was once believed to result in decreased cholesterol synthesis in the liver. Several studies have been published that indicate no overall reduction in total cholesterol occurs using various dosages of guggulsterone, and levels of low-density lipoprotein ("bad cholesterol") increased in many people. Nevertheless, guggulsterone is an ingredient in many nutritional supplements. Guggulsterone was also found to have interactions with the viral Adipose Ribose Phosphatase enzyme of SARS-CoV2 and can prove to be a potential candidate for the development of therapeutics for the treatment of COVID19.Guggulsterone is a broad-spectrum ligand of steroid hormone receptors, and is known to possess the following activities: Mineralocorticoid receptor antagonist (Ki = 39 nM) Progesterone receptor partial agonist (Ki = 201 nM) Glucocorticoid receptor antagonist (Ki = 224 nM) Androgen receptor antagonist (Ki = 240 nM) Estrogen receptor agonist (Ki > 5 μM; EC50 > 5 μM) Farnesoid X receptor antagonist (IC50 = 5–50 μM) Pregnane X receptor agonist (EC50 = 2.4 μM ((Z)-isomer))Guggulsterone has been found in animal research to be orally active; it has an absolute bioavailability of 42.9% after oral administration in rats, with a half-life of around 10 hours in this species, indicating a good pharmacokinetic profile.

WikidataRate this definition:0.0 / 0 votes

1. Guggulsterone

   Guggulsterone is a plant steroid found in the resin of the guggul plant, Commiphora mukul. Guggulsterone can exist as either of two stereoisomers, E-guggulsterone and Z-guggulsterone. In humans, it acts as an antagonist of the farnesoid X receptor, which was once believed to result in decreased cholesterol synthesis in the liver. Several studies have been published that indicate no overall reduction in total cholesterol occurs using various dosages of guggulsterone, and levels of low-density lipoprotein increased in many people. Nevertheless, guggulsterone is an ingredient in many nutritional supplements.

How to pronounce guggulsterone?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say guggulsterone in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of guggulsterone in Chaldean Numerology is: 1

2. Pythagorean Numerology

   The numerical value of guggulsterone in Pythagorean Numerology is: 9

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Guggulsterone
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Guggulsterone
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=guggulsterone