What does granzyme mean?

Definitions for granzyme
granzyme

Here are all the possible meanings and translations of the word granzyme.

Wiktionary

  1. granzyme(Noun)

    Any of a series of serine proteases that are released by cytoplasmic granules within natural killer cells.

Freebase

  1. Granzyme

    Granzymes are serine proteases that are released by cytoplasmic granules within cytotoxic T cells and natural killer cells. Their purpose is to induce apoptosis within virus-infected cells, thus destroying them. Cytotoxic T cells and natural killer cells release a protein called perforin, which attacks the target cells. Researchers used to think that perforin creates pores within the cell membranes, through which the granzymes can enter, inducing apoptosis. However, new evidence indicates that a multimeric complex can enter a cell through the mannose 6-phosphate receptor and is enclosed in a vesicle. Not mentioned in reference Perforin then allows GrB to pass through the vesicle surface and into the cell, causing apoptosis by various pathways. They do so by cleaving caspases, which in turn activates caspase-activated DNase. This enzyme degrades DNA, thus inducing apoptotic cascades. Also, GrB cleaves the protein Bid, which recruits the protein Bax and Bak to change the membrane permeability of the mitochondria, causing the release of cytochrome c, Smac/Diablo and Omi/HtrA2, among other proteins. As well, GrB is shown to cleave many of the chemicals responsible for apoptosis without the aid of caspase, as proven by experiments on caspase knockout mice CTL cells incubated with other cells.

How to pronounce granzyme?

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How to say granzyme in sign language?

  1. granzyme

Numerology

  1. Chaldean Numerology

    The numerical value of granzyme in Chaldean Numerology is: 1

  2. Pythagorean Numerology

    The numerical value of granzyme in Pythagorean Numerology is: 1

Images & Illustrations of granzyme

  1. granzyme

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Translations for granzyme

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"granzyme." Definitions.net. STANDS4 LLC, 2019. Web. 19 Oct. 2019. <https://www.definitions.net/definition/granzyme>.

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