What does granzyme mean?

Definitions for granzyme

Here are all the possible meanings and translations of the word granzyme.


  1. granzyme(Noun)

    Any of a series of serine proteases that are released by cytoplasmic granules within natural killer cells.


  1. Granzyme

    Granzymes are serine proteases that are released by cytoplasmic granules within cytotoxic T cells and natural killer cells. Their purpose is to induce apoptosis within virus-infected cells, thus destroying them. Cytotoxic T cells and natural killer cells release a protein called perforin, which attacks the target cells. Researchers used to think that perforin creates pores within the cell membranes, through which the granzymes can enter, inducing apoptosis. However, new evidence indicates that a multimeric complex can enter a cell through the mannose 6-phosphate receptor and is enclosed in a vesicle. Not mentioned in reference Perforin then allows GrB to pass through the vesicle surface and into the cell, causing apoptosis by various pathways. They do so by cleaving caspases, which in turn activates caspase-activated DNase. This enzyme degrades DNA, thus inducing apoptotic cascades. Also, GrB cleaves the protein Bid, which recruits the protein Bax and Bak to change the membrane permeability of the mitochondria, causing the release of cytochrome c, Smac/Diablo and Omi/HtrA2, among other proteins. As well, GrB is shown to cleave many of the chemicals responsible for apoptosis without the aid of caspase, as proven by experiments on caspase knockout mice CTL cells incubated with other cells.

How to pronounce granzyme?

  1. Alex
    US English

How to say granzyme in sign language?

  1. granzyme


  1. Chaldean Numerology

    The numerical value of granzyme in Chaldean Numerology is: 1

  2. Pythagorean Numerology

    The numerical value of granzyme in Pythagorean Numerology is: 1

Images & Illustrations of granzyme

  1. granzyme

Popularity rank by frequency of use


Translations for granzyme

From our Multilingual Translation Dictionary

Get even more translations for granzyme »


Find a translation for the granzyme definition in other languages:

Select another language:

  • - Select -
  • 简体中文 (Chinese - Simplified)
  • 繁體中文 (Chinese - Traditional)
  • Español (Spanish)
  • Esperanto (Esperanto)
  • 日本語 (Japanese)
  • Português (Portuguese)
  • Deutsch (German)
  • العربية (Arabic)
  • Français (French)
  • Русский (Russian)
  • ಕನ್ನಡ (Kannada)
  • 한국어 (Korean)
  • עברית (Hebrew)
  • Gaeilge (Irish)
  • Українська (Ukrainian)
  • اردو (Urdu)
  • Magyar (Hungarian)
  • मानक हिन्दी (Hindi)
  • Indonesia (Indonesian)
  • Italiano (Italian)
  • தமிழ் (Tamil)
  • Türkçe (Turkish)
  • తెలుగు (Telugu)
  • ภาษาไทย (Thai)
  • Tiếng Việt (Vietnamese)
  • Čeština (Czech)
  • Polski (Polish)
  • Bahasa Indonesia (Indonesian)
  • Românește (Romanian)
  • Nederlands (Dutch)
  • Ελληνικά (Greek)
  • Latinum (Latin)
  • Svenska (Swedish)
  • Dansk (Danish)
  • Suomi (Finnish)
  • فارسی (Persian)
  • ייִדיש (Yiddish)
  • հայերեն (Armenian)
  • Norsk (Norwegian)
  • English (English)

Discuss these granzyme definitions with the community:

Word of the Day

Would you like us to send you a FREE new word definition delivered to your inbox daily?

Please enter your email address:


Use the citation below to add this definition to your bibliography:


"granzyme." Definitions.net. STANDS4 LLC, 2020. Web. 15 Aug. 2020. <https://www.definitions.net/definition/granzyme>.

Are we missing a good definition for granzyme? Don't keep it to yourself...

Free, no signup required:

Add to Chrome

Get instant definitions for any word that hits you anywhere on the web!

Free, no signup required:

Add to Firefox

Get instant definitions for any word that hits you anywhere on the web!

Nearby & related entries:

Alternative searches for granzyme:

Thanks for your vote! We truly appreciate your support.