What does genetic heterogeneity mean?
Definitions for genetic heterogeneity
ge·net·ic het·ero·gene·ity
This dictionary definitions page includes all the possible meanings, example usage and translations of the word genetic heterogeneity.
Wikipedia
Genetic heterogeneity
Genetic heterogeneity occurs through the production of single or similar phenotypes through different genetic mechanisms. There are two types of genetic heterogeneity: allelic heterogeneity, which occurs when a similar phenotype is produced by different alleles within the same gene; and locus heterogeneity, which occurs when a similar phenotype is produced by mutations at different loci.
Wikidata
Genetic heterogeneity
Genetic Heterogeneity is a phenomenon in which a single phenotype or genetic disorder may be caused by any one of a multiple number of alleles or non-allele mutations. This is in contrast to pleiotropy, where a single gene may cause multiple phenotypic expressions or disorders. Genetic heterogeneity can be classified as either "allelic" or "locus". Allelic heterogeneity means that different mutations within a single gene locus cause the same phenotypic expression. For example, there are over 1000 known mutant alleles of the CFTR gene that cause cystic fibrosis. Locus heterogeneity means that variations in completely unrelated gene loci cause a single disorder. For example, retinitis pigmentosa has autosomal dominant, autosomal recessive, and X-linked origins. However, only one mutant locus is needed for the phenotype to manifest.
U.S. National Library of Medicine
Genetic Heterogeneity
The presence of apparently similar characters for which the genetic evidence indicates that different genes or different genetic mechanisms are involved in different pedigrees. In clinical settings genetic heterogeneity refers to the presence of a variety of genetic defects which cause the same disease, often due to mutations at different loci on the same gene, a finding common to many human diseases including ALZHEIMER DISEASE; CYSTIC FIBROSIS; LIPOPROTEIN LIPASE DEFICIENCY, FAMILIAL; and POLYCYSTIC KIDNEY DISEASES. (Rieger, et al., Glossary of Genetics: Classical and Molecular, 5th ed; Segen, Dictionary of Modern Medicine, 1992)
Numerology
Chaldean Numerology
The numerical value of genetic heterogeneity in Chaldean Numerology is: 6
Pythagorean Numerology
The numerical value of genetic heterogeneity in Pythagorean Numerology is: 3
Translations for genetic heterogeneity
From our Multilingual Translation Dictionary
- 遺伝的異質性Japanese
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"genetic heterogeneity." Definitions.net. STANDS4 LLC, 2024. Web. 26 Apr. 2024. <https://www.definitions.net/definition/genetic+heterogeneity>.
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