Definitions for genetic disorder
ge·net·ic dis·or·der

Princeton's WordNetRate this definition:0.0 / 0 votes

1. genetic disease, genetic disorder, genetic abnormality, genetic defect, congenital disease, inherited disease, inherited disorder, hereditary disease, hereditary conditionnoun

   a disease or disorder that is inherited genetically

WikipediaRate this definition:0.0 / 0 votes

1. Genetic disorder

   A genetic disorder is a health problem caused by one or more abnormalities in the genome. It can be caused by a mutation in a single gene (monogenic) or multiple genes (polygenic) or by a chromosomal abnormality. Although polygenic disorders are the most common, the term is mostly used when discussing disorders with a single genetic cause, either in a gene or chromosome. The mutation responsible can occur spontaneously before embryonic development (a de novo mutation), or it can be inherited from two parents who are carriers of a faulty gene (autosomal recessive inheritance) or from a parent with the disorder (autosomal dominant inheritance). When the genetic disorder is inherited from one or both parents, it is also classified as a hereditary disease. Some disorders are caused by a mutation on the X chromosome and have X-linked inheritance. Very few disorders are inherited on the Y chromosome or mitochondrial DNA (due to their size).There are well over 6,000 known genetic disorders, and new genetic disorders are constantly being described in medical literature. More than 600 genetic disorders are treatable. Around 1 in 50 people are affected by a known single-gene disorder, while around 1 in 263 are affected by a chromosomal disorder. Around 65% of people have some kind of health problem as a result of congenital genetic mutations. Due to the significantly large number of genetic disorders, approximately 1 in 21 people are affected by a genetic disorder classified as "rare" (usually defined as affecting less than 1 in 2,000 people). Most genetic disorders are rare in themselves.Genetic disorders are present before birth, and some genetic disorders produce birth defects, but birth defects can also be developmental rather than hereditary. The opposite of a hereditary disease is an acquired disease. Most cancers, although they involve genetic mutations to a small proportion of cells in the body, are acquired diseases. Some cancer syndromes, however, such as BRCA mutations, are hereditary genetic disorders.

WikidataRate this definition:5.0 / 1 vote

1. Genetic disorder

   A genetic disorder is an illness caused by one or more abnormalities in the genome, especially a condition that is present from birth. Most genetic disorders are quite rare and affect one person in every several thousands or millions. Genetic disorders are heritable, and are passed down from the parents' genes. Other defects may be caused by new mutations or changes to the DNA. In such cases, the defect will only be heritable if it occurs in the germ line. The same disease, such as some forms of cancer, may be caused by an inherited genetic condition in some people, by new mutations in other people, and by nongenetic causes in still other people. Some types of recessive gene disorders confer an advantage in certain environments when only one copy of the gene is present.

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1. • Disease

How to pronounce genetic disorder?

1. Alex

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How to say genetic disorder in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of genetic disorder in Chaldean Numerology is: 9

2. Pythagorean Numerology

   The numerical value of genetic disorder in Pythagorean Numerology is: 2

Examples of genetic disorder in a Sentence

1. Michel Milinkovitch:

   This study potentially establishes a link between a human pathological condition and the skin of African elephants, strikingly, we show strong similarities between the normal skin morphology of African elephants and that of humans affected by' ichthyosis vulgaris,' a common genetic disorder affecting about 1 in 250 people that is known to impact shedding of the skin and cause dry, scaly skin.

2. Marie Budev:

   Joyce Smith said. She had a second chance at life. She knew she had the second chance and she was lucky to have that. For much of her earlier life in Massachusetts, Mellady was hobbled by a mysterious lung condition. Then, in her late 30s, she tested positive foralpha-1 antitrypsin deficiency, a genetic disorder. The inherited condition predisposes people to lung conditions like chronic obstructive pulmonary disease and the emphysema Mellady developed before her transplant. The condition is caused by a lack of a protein in the blood called alpha-1 antitrypsin, which protects the lungs from inflammation. When Melladys lungs were replaced in 2007, doctors at theCleveland Clinicsaid they were among the worst they had ever seen, functioning at 15 percent of capacity. Over the next 13 years, Mellady served as an inspiration for other patients about to undergo similar transplants, a source of support for their relatives and a wealth of information for doctors studying her condition. She ended up living more than twice as long on her new lungs as the average 6.3 years for lung transplant patients. Dr. Marie Budev, the medical director of Cleveland Clinics lung and heart-lung transplant program, oversaw Melladys care and said Marie Budev was the first person from the program who died of COVID-19 and second to test positive. In this December 2016 photo provided by Joyce Smith, Joanne Mellady and Joyce Smith dog Oscar sled down the driveway of Joyce Smith home in Washington, N.H. Mellady, who received a double lung transplant in 2007, died of the coronavirus on March 30, 2020. Joyce Smith was 67. That scared Budev because transplant recipients are seen as particularly vulnerable to the virus because of the drugs they take that suppress their immune systems, making them more susceptible to infections. Five other people who have had lungs transplanted by the clinic have been infected by the virus and one more has has died. Marie Budev said Melladys death was devastating because she had become a testament to the possibilities of how to live life to the fullest after receiving an organ transplant. Marie Budev knew this was a lease on life that Marie Budev had gotten, Marie Budev said. Mellady participated in several research projects in Boston related to Marie Budev condition and was active in groups looking for a cure for alpha-1 antitrypsin deficiency and who supportedorgan donation. Marie Budev was just blooming with excitement to help others and help the field of medicine especially transplantation.

3. Dennis Lo:

   We have demonstrated that this method enables us to sequence the whole genome of a fetus, which means it could be used to test for virtually any genetic disorder.

4. Susan Klugman:

   The risk that we quote to patients is about a 1-in-500 loss rate, that is clearly a much, much smaller risk than( inheriting) any genetic disorder.

5. The FDA:

   No test is perfect, given the probability of erroneous results and the rarity of these mutations, professional societies typically recommend that only prospective parents with a family history of a genetic disorder undergo carrier screening.

References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=genetic disorder
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Genetic_Disorder
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=genetic disorder