Definitions for frameshift mutation
frameshift muta·tion

WiktionaryRate this definition:0.0 / 0 votes

1. frameshift mutationnoun

   a genetic mutation that either inserts or deletes a series of nucleotides that is not divisible by three and thus disrupts gene expression by codons

WikipediaRate this definition:0.0 / 0 votes

1. Frameshift mutation

   A frameshift mutation (also called a framing error or a reading frame shift) is a genetic mutation caused by indels (insertions or deletions) of a number of nucleotides in a DNA sequence that is not divisible by three. Due to the triplet nature of gene expression by codons, the insertion or deletion can change the reading frame (the grouping of the codons), resulting in a completely different translation from the original. The earlier in the sequence the deletion or insertion occurs, the more altered the protein. A frameshift mutation is not the same as a single-nucleotide polymorphism in which a nucleotide is replaced, rather than inserted or deleted. A frameshift mutation will in general cause the reading of the codons after the mutation to code for different amino acids. The frameshift mutation will also alter the first stop codon ("UAA", "UGA" or "UAG") encountered in the sequence. The polypeptide being created could be abnormally short or abnormally long, and will most likely not be functional.Frameshift mutations are apparent in severe genetic diseases such as Tay–Sachs disease; they increase susceptibility to certain cancers and classes of familial hypercholesterolaemia; in 1997, a frameshift mutation was linked to resistance to infection by the HIV retrovirus. Frameshift mutations have been proposed as a source of biological novelty, as with the alleged creation of nylonase, however, this interpretation is controversial. A study by Negoro et al (2006) found that a frameshift mutation was unlikely to have been the cause and that rather a two amino acid substitution in the active site of an ancestral esterase resulted in nylonase.

WikidataRate this definition:0.0 / 0 votes

1. Frameshift mutation

   A frameshift mutation is a genetic mutation caused by indels of a number of nucleotides in a DNA sequence that is not divisible by three. Due to the triplet nature of gene expression by codons, the insertion or deletion can change the reading frame, resulting in a completely different translation from the original. The earlier in the sequence the deletion or insertion occurs, the more altered the protein. A frameshift mutation is not the same as a single-nucleotide polymorphism in which a nucleotide is replaced, rather than inserted or deleted. A frameshift mutation will in general cause the reading of the codons after the mutation to code for different amino acids. The frameshift mutation will also alter the first stop codon encountered in the sequence. The polypeptide being created could be abnormally short or abnormally long, and will most likely not be functional. Frameshift mutations are apparent in severe genetic diseases such as Tay-Sachs disease, HIV, cancers, Cystic Fibrosis and hypercholestrolemia. Frameshift mutations have also been proposed as a source of biological novelty, as with the alleged creation of nylonase, however, this interpretation is controversial. A study by Negoro et al found that a frameshift mutation was unlikely to have been the cause and that rather a two amino acid substitution in the catalytic cleft of an ancestral esterase amplified Ald-hydrolytic activity.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Frameshift Mutation

   A type of mutation in which a number of NUCLEOTIDES deleted from or inserted into a protein coding sequence is not divisible by three, thereby causing an alteration in the READING FRAMES of the entire coding sequence downstream of the mutation. These mutations may be induced by certain types of MUTAGENS or may occur spontaneously.

How to pronounce frameshift mutation?

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Numerology

1. Chaldean Numerology

   The numerical value of frameshift mutation in Chaldean Numerology is: 1

2. Pythagorean Numerology

   The numerical value of frameshift mutation in Pythagorean Numerology is: 2

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Frameshift_Mutation
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Frameshift_Mutation
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=frameshift mutation