Definitions for drug discovery
drug dis·cov·e·ry

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1. Drug discovery

   In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered through identifying the active ingredient from traditional remedies or by serendipitous discovery. Later chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole organisms to identify substances that have a desirable therapeutic effect in a process known as classical pharmacology. Since sequencing of the human genome which allowed rapid cloning and synthesis of large quantities of purified proteins, it has become common practice to use high throughput screening of large compounds libraries against isolated biological targets which are hypothesized to be disease modifying in a process known as reverse pharmacology. Hits from these screens are then tested in cells and then in animals for efficacy. Even more recently, scientists have been able to understand the shape of biological molecules at the atomic level, and to use that knowledge to design drug candidates. Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity, efficacy/potency, metabolic stability, and oral bioavailability. Once a compound that fulfills all of these requirements has been identified, it will begin the process of drug development prior to clinical trials. One or more of these steps may, but not necessarily, involve computer-aided drug design.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Drug Discovery

   The process of finding chemicals for potential therapeutic use.

How to pronounce drug discovery?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say drug discovery in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of drug discovery in Chaldean Numerology is: 2

2. Pythagorean Numerology

   The numerical value of drug discovery in Pythagorean Numerology is: 8

Examples of drug discovery in a Sentence

1. Olivia Rossanese:

   This Darwinian approach to drug discovery gives us the best chance yet of defeating cancer.

2. Maddie LaRue:

   [ Drug companies ] really utilize the scientific literature, and most of the literature is coming out of big academic labs, if academic labs are shut down for months and research continuities are disrupted, it's going to take several more months to gain momentum again and people won't be producing results for some time... That could really put a lag on the drug discovery pipeline that we have going with industry.

References

1. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=drug discovery