Definitions for down syndrome
down syn·drome

Princeton's WordNetRate this definition:0.0 / 0 votes

1. mongolism, mongolianism, Down's syndrome, Down syndrome, trisomy 21noun

   a congenital disorder caused by having an extra 21st chromosome; results in a flat face and short stature and mental retardation

WiktionaryRate this definition:0.0 / 0 votes

1. Down syndromenoun

   Condition caused by a chromosomal excess, whereby the patients bear a certain resemblance to the Mongoloid race, such as a small head and tilted eyelids.

2. Etymology: Named after John L.H. Langdon-Down (1828-1896), an English physician who described it in the late 1800s. The term was first used in 1961.

WikipediaRate this definition:0.0 / 0 votes

1. Down syndrome

   Down syndrome or Down's syndrome, also known as trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. It is usually associated with physical growth delays, mild to moderate intellectual disability, and characteristic facial features. The average IQ of a young adult with Down syndrome is 50, equivalent to the mental ability of an eight- or nine-year-old child, but this can vary widely.The parents of the affected individual are usually genetically normal. The probability increases from less than 0.1% in 20-year-old mothers to 3% in those of age 45. The extra chromosome is believed to occur by chance, with no known behavioral activity or environmental factor that changes the probability. Down syndrome can be identified during pregnancy by prenatal screening followed by diagnostic testing or after birth by direct observation and genetic testing. Since the introduction of screening, Down syndrome pregnancies are often aborted (rates varying from 50%-85% depending on maternal age, gestational age, and maternal race/ethnicity).There is no cure for Down syndrome. Education and proper care have been shown to improve quality of life. Some children with Down syndrome are educated in typical school classes, while others require more specialized education. Some individuals with Down syndrome graduate from high school, and a few attend post-secondary education. In adulthood, about 20% in the United States do paid work in some capacity, with many requiring a sheltered work environment. Support in financial and legal matters is often needed. Life expectancy is around 50 to 60 years in the developed world with proper health care. Regular screening for health problems common in Down syndrome is recommended throughout the person's life.Down syndrome is one of the most common chromosome abnormalities in humans. It occurs in about 1 in 1,000 babies born each year. In 2015, Down syndrome was present in 5.4 million individuals globally and resulted in 27,000 deaths, down from 43,000 deaths in 1990. It is named after British doctor John Langdon Down, who fully described the syndrome in 1866. Some aspects of the condition were described earlier by French psychiatrist Jean-Étienne Dominique Esquirol in 1838 and French physician Édouard Séguin in 1844. The genetic cause of Down syndrome was discovered in 1959.

ChatGPTRate this definition:0.0 / 0 votes

1. down syndrome

   Down Syndrome, also known as trisomy 21, is a genetic disorder caused by the presence of an extra 21st chromosome. This additional chromosome results in a range of physical characteristics, intellectual and developmental issues. Features may include mild to moderate intellectual disability, delayed developmental milestones, distinctive facial features, and an increased risk of certain medical conditions. It impacts the person's physical growth and their ability to learn and develop mentally. The severity of these symptoms varies from person to person.

WikidataRate this definition:0.0 / 0 votes

1. Down syndrome

   Down syndrome or Down's syndrome, also known as trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. Down syndrome is the most common chromosome abnormality in humans. It is typically associated with a delay in cognitive ability and physical growth, and a particular set of facial characteristics. The average IQ of young adults with Down syndrome is around 50, whereas young adults without the condition typically have an IQ of 100. A large proportion of individuals with Down syndrome have a severe degree of intellectual disability. Down syndrome is named after John Langdon Down, the British physician who described the syndrome in 1866. The condition was clinically described earlier by Jean Etienne Dominique Esquirol in 1838 and Edouard Seguin in 1844. Down syndrome was identified as a chromosome 21 trisomy by Dr. Jérôme Lejeune in 1959. Down syndrome can be identified in a newborn by direct observation or in a fetus by prenatal screening. Pregnancies with this diagnosis are often terminated. The CDC estimates that about one of every 691 babies born in the United States each year is born with Down syndrome.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Down Syndrome

   A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe MENTAL RETARDATION. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)

Matched Categories

1. • Birth Defect
   • Trisomy

How to pronounce down syndrome?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say down syndrome in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of down syndrome in Chaldean Numerology is: 8

2. Pythagorean Numerology

   The numerical value of down syndrome in Pythagorean Numerology is: 7

Examples of down syndrome in a Sentence

1. Heather Bradley:

   I think it really normalizes Down syndrome and helps people see we are really like any other family.

2. Roseanne Stuart:

   I think it is time people realized that people with Down syndrome can be beautiful and should be celebrated, she is not insecure in the least bit, but I have made a point of never letting anyone be critical of her and telling her every day how amazing, funny, smart, beautiful, wonderful she is.

3. Maggie Gaines:

   It was very clear from the beginning that she didn't understand what she was saying, her having Down syndrome is one aspect of it, but I'm sure most six year olds don't understand what that means.

4. Courtney Baker:

   I came to you during the most difficult time in my life. I was terrified, anxious and in complete despair. I didn’t know the truth yet about my baby, and that’s what I desperately needed from you, but instead of support and encouragement, you suggested we terminate our child. I told you her name, and you asked us again if we understood how low our quality of life would be with a child with Down syndrome. You suggested we reconsider our decision to continue the pregnancy.

5. Rob Scott:

   Down syndrome is literally one of the most beautiful things that’s ever happened in my life.

References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=down syndrome
2. ^ Wiktionary
   https://en.wiktionary.org/wiki/Down_Syndrome
3. ^ Wikipedia
   https://en.wikipedia.org/wiki/Down_Syndrome
4. ^ ChatGPT
   https://chat.openai.com
5. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=down syndrome