What does dna polymerase i mean?
Definitions for dna polymerase i
dna poly·merase i
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Wikidata
DNA polymerase I
DNA Polymerase I is an enzyme that participates in the process of DNA replication. Discovered by Arthur Kornberg in 1956, it was the first known DNA polymerase. It was initially characterized in E. coli, although it is ubiquitous in prokaryotes. In E. coli and many other bacteria, the gene that encodes Pol I is known as polA. The E. coli form of the enzyme is composed of 928 amino acids, and is an example of a processive enzyme - it can sequentially catalyze multiple polymerisations. Pol I possesses four enzymatic activities: ⁕A 5' -> 3' DNA-Dependent DNA polymerase activity, requiring a 3' primer site and a template strand ⁕A 3' -> 5' exonuclease activity that mediates proofreading ⁕A 5' -> 3' exonuclease activity mediating nick translation during DNA repair. ⁕A 5' -> 3' RNA-Dependent DNA polymerase activity. Pol I operates on RNA templates with considerably lower efficiency than it does DNA templates, and this activity is probably of only limited biological significance. In the replication process, DNA Polymerase I removes the RNA primer from the lagging strand and fills in the necessary nucleotides between the Okazaki fragments in 5' -> 3' direction, proofreading for mistakes as it goes. It is a template-dependent enzyme - it only adds nucleotides that correctly base pair with an existing DNA strand acting as a template. DNA Ligase then joins the various fragments together into a continuous strand of DNA.
U.S. National Library of Medicine
DNA Polymerase I
A DNA-dependent DNA polymerase characterized in prokaryotes and may be present in higher organisms. It has both 3'-5' and 5'-3' exonuclease activity, but cannot use native double-stranded DNA as template-primer. It is not inhibited by sulfhydryl reagents and is active in both DNA synthesis and repair. EC 2.7.7.7.
Numerology
Chaldean Numerology
The numerical value of dna polymerase i in Chaldean Numerology is: 5
Pythagorean Numerology
The numerical value of dna polymerase i in Pythagorean Numerology is: 4
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"dna polymerase i." Definitions.net. STANDS4 LLC, 2024. Web. 28 Apr. 2024. <https://www.definitions.net/definition/dna+polymerase+i>.
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