Definitions for dextromethorphan
dex·tromethor·phan

WiktionaryRate this definition:0.0 / 0 votes

1. dextromethorphannoun

   An antitussive drug (a cough suppressant) that is found in many over-the-counter cold and cough preparations.

WikipediaRate this definition:0.0 / 0 votes

1. Dextromethorphan

   Dextromethorphan (DXM) is a cough suppressant in over-the-counter cold and cough medicines. It affects NMDA, glutamate-1, and sigma-1 receptors in the brain, all of which have been implicated in the pathophysiology of depression. In 2022, the FDA approved a formulation of it combined with bupropion named Auvelity to serve as a rapid acting antidepressant in patients with major depressive disorder. It is sold in syrup, instant release tablet, extended release tablet, spray, and lozenge forms. It is in the morphinan class of medications with sedative, dissociative, and stimulant properties (at lower doses). Dextromethorphan does not have a significant affinity for the mu-opioid receptor activity typical of morphinan compounds and exerts its therapeutic effects through several other receptors. In its pure form, dextromethorphan occurs as a white powder.Dextromethorphan is also used recreationally. When exceeding approved dosages, dextromethorphan acts as a dissociative hallucinogen. It has multiple mechanisms of action, including actions as a nonselective serotonin reuptake inhibitor and a sigma-1 receptor agonist. Dextromethorphan and its major metabolite, dextrorphan, also block the NMDA receptor at high doses, which produces effects similar to other dissociative anesthetics such as ketamine, nitrous oxide, and phencyclidine. It was patented in 1949 and approved for medical use in 1953.

WikidataRate this definition:4.0 / 2 votes

1. Dextromethorphan

   Dextromethorphan is an antitussive drug. It is one of the active ingredients in many over-the-counter cold and cough medicines, including generic labels and store brands, Benylin DM, Mucinex DM, Robitussin, NyQuil, Dimetapp, Vicks, Coricidin, Delsym, TheraFlu, and others. Dextromethorphan has also found other uses in medicine, ranging from pain relief to psychological applications. It is sold in syrup, tablet, spray, and lozenge forms. In its pure form, dextromethorphan occurs as a white powder. DXM is also used recreationally. When exceeding label-specified maximum dosages, dextromethorphan acts as a dissociative hallucinogen. Its mechanism of action is via multiple effects, including actions as a nonselective serotonin reuptake inhibitor and a sigma-1 receptor agonist. The major metabolite of DXM, dextrorphan, also acts as an NMDA receptor antagonist. In high doses this produces effects similar to, yet distinct from, the dissociative states created by other hallucinogens such as ketamine and phencyclidine. As well, the metabolite 3-methoxymorphinan of dextrorphan produces local anesthetic effects in rats with potency above dextrorphan, but below that of DXM.

U.S. National Library of MedicineRate this definition:5.0 / 1 vote

1. Dextromethorphan

   Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.

How to pronounce dextromethorphan?

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Numerology

1. Chaldean Numerology

   The numerical value of dextromethorphan in Chaldean Numerology is: 1

2. Pythagorean Numerology

   The numerical value of dextromethorphan in Pythagorean Numerology is: 6

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References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Dextromethorphan
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Dextromethorphan
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=dextromethorphan