What does cortodoxone mean?
Definitions for cortodoxone
corto·dox·one
This dictionary definitions page includes all the possible meanings, example usage and translations of the word cortodoxone.
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Wikipedia
cortodoxone
11-Deoxycortisol, also known as cortodoxone (INN), cortexolone as well as 17α,21-dihydroxyprogesterone or 17α,21-dihydroxypregn-4-ene-3,20-dione, is an endogenous glucocorticoid steroid hormone, and a metabolic intermediate towards cortisol. It was first described by Tadeusz Reichstein in 1938 as Substance S, thus has also been referred to as Reichstein's Substance S or Compound S.
Wikidata
Cortodoxone
Cortodoxone, also known as cortexolone or 11-deoxycortisol, is a steroid that can be oxygenated to cortisol. It was first synthesized by Tadeusz Reichstein. On April 5, 1952, biochemist Durey Peterson and microbiologist Herbert Murray at Upjohn published the first report of a breakthrough fermentation process for the microbial 11α-oxygenation of steroids in a single step by common molds of the order Mucorales. 11α-oxygenation of cortodoxone produces 11α-hydrocortisone, which can be chemically oxidized to cortisone, or converted by further chemical steps to cortisol. Subsequent fermentation processes for the microbial 11β-oxygenation of steroids in a single step were developed that could convert cortodoxone directly to cortisol. Cortodoxone functions as a glucocorticoid, though is less potent than cortisol. It can be synthesized from 17-hydroxyprogesterone. In 11β-hydroxylase deficiency, cortodoxone levels increase dramatically, causing hypertension. Cortodoxone can also be converted to androstenedione. This could explain, at least in part, the marked increase in androstenedione levels in 11β-hydroxylase deficiency.
U.S. National Library of Medicine
Cortodoxone
17,21-Dihydroxypregn-4-ene-3,20-dione. A 17-hydroxycorticosteroid with glucocorticoid and anti-inflammatory activities.
Numerology
Chaldean Numerology
The numerical value of cortodoxone in Chaldean Numerology is: 2
Pythagorean Numerology
The numerical value of cortodoxone in Pythagorean Numerology is: 4
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"cortodoxone." Definitions.net. STANDS4 LLC, 2024. Web. 5 May 2024. <https://www.definitions.net/definition/cortodoxone>.
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