What does complement c3-c5 convertases, classical pathway mean?
Definitions for complement c3-c5 convertases, classical pathway
com·ple·men·t c3-c5 con·ver·tases, clas·si·cal path·way
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Wikipedia
complement c3-c5 convertases, classical pathway
The classical complement pathway is one of three pathways which activate the complement system, which is part of the immune system. The classical complement pathway is initiated by antigen-antibody complexes with the antibody isotypes IgG and IgM.Following activation, a series of proteins are recruited to generate C3 convertase (C4b2b, historically referred C4b2a), which cleaves the C3 protein. The C3b component of the cleaved C3 binds to C3 convertase (C4b2b) to generate C5 convertase (C4b2b3b), which cleaves the C5 protein. The cleaved products attract phagocytes to the site of infection and tags target cells for elimination by phagocytosis. In addition, the C5 convertase initiates the terminal phase of the complement system, leading to the assembly of the membrane attack complex (MAC). The membrane attack complex creates a pore on the target cell's membrane, inducing cell lysis and death.The classical complement pathway can also be activated by apoptotic cells, necrotic cells, and acute phase proteins.
U.S. National Library of Medicine
Complement C3-C5 Convertases, Classical Pathway
Important enzymes in the CLASSICAL COMPLEMENT ACTIVATION PATHWAY. They cleave COMPLEMENT C3 and COMPLEMENT C5.
Numerology
Chaldean Numerology
The numerical value of complement c3-c5 convertases, classical pathway in Chaldean Numerology is: 1
Pythagorean Numerology
The numerical value of complement c3-c5 convertases, classical pathway in Pythagorean Numerology is: 4
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