Definitions for colistin
kəˈlɪs tɪncol·istin

WiktionaryRate this definition:0.0 / 0 votes

1. colistinnoun

   A polymixin antibiotic effective against a range of gram-negative bacteria

WikipediaRate this definition:0.0 / 0 votes

1. Colistin

   Colistin, also known as polymyxin E, is an antibiotic medication used as a last-resort treatment for multidrug-resistant Gram-negative infections including pneumonia. These may involve bacteria such as Pseudomonas aeruginosa, Klebsiella pneumoniae, or Acinetobacter. It comes in two forms: colistimethate sodium can be injected into a vein, injected into a muscle, or inhaled, and colistin sulfate is mainly applied to the skin or taken by mouth. Colistimethate sodium is a prodrug; it is produced by the reaction of colistin with formaldehyde and sodium bisulfite, which leads to the addition of a sulfomethyl group to the primary amines of colistin. Colistimethate sodium is less toxic than colistin when administered parenterally. In aqueous solutions it undergoes hydrolysis to form a complex mixture of partially sulfomethylated derivatives, as well as colistin. Resistance to colistin began to appear as of 2015.Common side effects of the injectable form include kidney problems and neurological problems. Other serious side effects may include anaphylaxis, muscle weakness, and Clostridium difficile-associated diarrhea. The inhaled form may result in constriction of the bronchioles. It is unclear if use during pregnancy is safe for the fetus. Colistin is in the polymyxin class of medications. It works by breaking down the cytoplasmic membrane, which generally results in bacterial cell death.Colistin was discovered in 1947 and colistimethate sodium was approved for medical use in the United States in 1970. It is on the World Health Organization's List of Essential Medicines. The World Health Organization classifies colistin as critically important for human medicine. It is available as a generic medication. It is derived from bacteria of the genus Paenibacillus.

WikidataRate this definition:0.0 / 0 votes

1. Colistin

   Colistin is a polymyxin antibiotic produced by certain strains of Bacillus polymyxa var. colistinus. Colistin is a mixture of cyclic polypeptides colistin A and B. Colistin is effective against most Gram-negative bacilli and is used as a polypeptide antibiotic. Colistin is a decades-old drug that fell out of favor due to its nephrotoxicity. It remains one of the last-resort antibiotics for multidrug-resistant Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter. New Delhi metallo-β-lactamase multidrug-resistant Enterobacteriaceae have also shown susceptibility to Colistin.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Colistin

   Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.

How to pronounce colistin?

1. Alex

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Numerology

1. Chaldean Numerology

   The numerical value of colistin in Chaldean Numerology is: 9

2. Pythagorean Numerology

   The numerical value of colistin in Pythagorean Numerology is: 2

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References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Colistin
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Colistin
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=colistin