Definitions for coactivator
coac·ti·va·tor

WiktionaryRate this definition:0.0 / 0 votes

1. coactivatornoun

   Any protein that binds to an activator as part of gene transcription

WikipediaRate this definition:0.0 / 0 votes

1. coactivator

   A coactivator is a type of transcriptional coregulator that binds to an activator (a transcription factor) to increase the rate of transcription of a gene or set of genes. The activator contains a DNA binding domain that binds either to a DNA promoter site or a specific DNA regulatory sequence called an enhancer. Binding of the activator-coactivator complex increases the speed of transcription by recruiting general transcription machinery to the promoter, therefore increasing gene expression. The use of activators and coactivators allows for highly specific expression of certain genes depending on cell type and developmental stage.Some coactivators also have histone acetyltransferase (HAT) activity. HATs form large multiprotein complexes that weaken the association of histones to DNA by acetylating the N-terminal histone tail. This provides more space for the transcription machinery to bind to the promoter, therefore increasing gene expression.Activators are found in all living organisms, but coactivator proteins are typically only found in eukaryotes because they are more complex and require a more intricate mechanism for gene regulation. In eukaryotes, coactivators are usually proteins that are localized in the nucleus.

WikidataRate this definition:0.0 / 0 votes

1. Coactivator

   A coactivator is a protein that increases gene expression by binding to an activator which contains a DNA binding domain. The coactivator is unable to bind DNA by itself. The coactivator can enhance transcription initiation by stabilizing the formation of the RNA polymerase holoenzyme enabling faster clearance of the promoter. Coactivators may control many other substeps of transcription, including elongation, RNA splicing, and termination and degradation of the coactivator-activator complex. Some coactivators possess intrinsic histone acetyltransferase activity, which acetylates histones and causes chromatin to relax in a limited region allowing increased access to the DNA. CBP and p300 are examples of coactivators with HAT activity. Numerous other enzyme activities have been reported among the 300 known coactivators for nuclear receptors. The most well known of these are SRC-1, SRC-2, and SRC-3. Coactivators work in high molecular weight complexes of 6-10 coactivator and coactivator-associated proteins. The same coactivator will likely be used to increase transcription of many different genes, since it is the activator that provides the specificity to a particular sequence. Recent evidence indicates that coactivators may have diverse roles outside of transcription and that they may act as 'master genes' for regulating major cellular and metabolic growth processes.

How to pronounce coactivator?

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Numerology

1. Chaldean Numerology

   The numerical value of coactivator in Chaldean Numerology is: 3

2. Pythagorean Numerology

   The numerical value of coactivator in Pythagorean Numerology is: 1

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References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Coactivator
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Coactivator
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=coactivator